摘要
海洋是生物资源的巨大宝库,地球上约80%的物种栖息在海洋中。由于特殊的生存环境,海洋生物可合成与陆地生物结构不同的、活性不一的代谢产物,为新药的研究与开发提供了大量的先导化合物。在过去的几十年间,全球范围内已从海洋动、植物及微生物中分离得到15 000多个化合物,其中头孢霉素、芋螺毒素、阿糖胞苷和阿糖腺苷等4个药物均是以海洋来源先导化合物为基础开发成功的。
The ocean is a huge resource of organisms and about 80 % of the world species live in it. Marine organisms synthesize various structurally-unique and pharmacologically-active metabolites which differ from those derived from the land organisms and serve as lead compounds for drug development. More than 15 000 new compounds have been isolated and identified from marine animals, plants and microorganisms since decades ago, and drugs like cephalosporins, ziconotide （Priah）, cytarahine （AraC） and vidarabine （AraA） were developed using these compounds as precursors.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2006年第1期5-7,共3页
Academic Journal of Second Military Medical University
