摘要
鼻咽癌是中国人,特别是中国南方人的一种常见癌症;世界上除其他少数族群具有中等程度的发病率以外,它是一种罕见的癌症。鼻咽癌多见于男性,男女发病率之比约为3∶1,且好发于中年人。现今已有令人信服的证据,支持EB病毒(国际癌症研究协会归属为第一类人体肿瘤病毒)是鼻咽癌的致病因子,肯定参与鼻咽癌的多阶段、多因素发生过程。本文简要地复阅了EB病毒在鼻咽癌发病机理中的作用,重点地介绍了EB病毒抗体和EB病毒DNA作为鼻咽癌标志的主要应用;根据由鼻咽癌导致的EB病毒抗体反应的现代知识,并考虑到目前可采用的检测技术,提出了促进有效地早期发现鼻咽癌的血清学筛选策略。
Nasopharyngeal carcinoma （NPC） is a common cancer among Chinese, especially Southern Chinese; except for a few other ethnic groups with moderate incidence, it is otherwise a rare cancer in the world. NPC has a male dominance of about 3：1 and mainly afflicts people in mid- life. There is now compelling evidences to suggest that Epstein-Barr virus （EBV）, a category I human tumor virus defined by UICC （International Agency for Research on Cancer） in 1997, is a causal agent of NPC and is most likely to be involved in the multi-step and multi-factorial development of NPC. In this article, the role of EBV in pathogenesis of NPC is reviewed briefly, and principle applications of EBV antibodies and EBV DNA as markers of NPC are outlined. Based on current knowledge of EBV antibody responses by NPC and taking available testing technologies into account, serologic screening strategy to facilitate efficient early detection of NPC is formulated.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2006年第2期250-256,共7页
Chinese Journal of Cancer
关键词
鼻咽肿瘤/病因学
EB病毒
血清学检测
Nasopharyngeal neoplasms/etiology
Epstein-Barr virus
Serologic detection
