摘要
目的研究T淋巴瘤侵袭转移基因Tiam1(Tlymphoma invasion/metastasis1)表达与喉癌浸润转移的关系。方法应用逆转录聚合酶链反应(RT-PCR)检测30例喉癌组织、12例喉癌转移的颈部淋巴结和10例正常喉部组织Tiam1mRNA的表达。结果有颈淋巴结转移和无颈淋巴结转移的喉癌原发灶Tiam1mRNA高表达率分别为75%(6/8)和18·2%(4/22),P=0·0072;有癌转移和无癌转移的淋巴结Tiam1mRNA高表达率分别为100%(8/8)和25%(1/4),P=0·0182。30例喉癌有10例Tiam1mRNA高表达,高表达率为33·3%。结论Tiam1mRNA表达与喉癌浸润转移呈相关关系。
Objective To study the relation between Tiaml gene（ T lymphoma invasion/metastasis 1 ）and carcinomas of larynx metastasized to lymph node. Method Using reverse transcription polymerase chain （RT-PCR） mRNA overexpression of Tiaml gene in 30 cases of carcinoma of larynx tissue, 12 lymph nodes and 10 cases of normal larynx tissue was studied. Result The frequency of TIAM1 overexpression was 75% （6/8） in primary carcinomas of larynx with metastasis but only 18.7% （4/22） in those without metastasis（ P = 0. 0072）. Overexpression of TIAM1 in metastasized lymph nodes was observed in 100% （8/8） of lymph nodes with metastasis but in only 25% （1/4） of the lymph nodes without metastasis of carcinoma（ P = 0. 0182）. The frequency of TIAM1 overexpression was 33.3% （10/30） in primary carcinomas of larynx. Conclusion Our data suggest that the overexpression of the TIAM1 gene correlates with lymph node metastasis of carcinomas of larynx.
出处
《临床检验杂志》
CAS
CSCD
北大核心
2006年第1期49-51,共3页
Chinese Journal of Clinical Laboratory Science
基金
广西科学基金资助项目(NO桂科青0229030)。
关键词
喉癌
淋巴结转移
Tiam
1基因
MRNA表达
carcinoma of larynx
Tiam1 gene
lymph node metastasis
mRNA overexpression
