摘要
目的 探讨绝经后妇女骨质疏松的发病机理及瘦素在骨质疏松中的作用。方法 志愿者健康女性各年龄组分别为：25～34岁37例，35～44岁31例，45～54岁30例，绝经期5年以上55～65岁40例，各组间BMI差异无显著性。并以绝经期5年以上55～65岁40例与25～34岁育龄女性37例对照，所有研究对象均做腰椎2～4前后位BMD值测定均空腹抽血，血清Leptin、IL-6、E2、T、FSH、LH、BGP的测定均为放射免疫法。TRAP、ALP为生化法。结果 非肥胖女性随着年龄的增大，Leptin呈上升趋势、BGP升高（P〈0.01），瘦素相关的成骨增强；绝经后女性FSH上升，E2下降（P〈0.001）；IL-6、TRAP升高、BMD下降，（P〈0.01）；绝经后妇女E2下降，骨吸收增强。结论 随着女性年龄的增加，瘦素升高，骨钙素升高，骨形成增加，瘦素是女性骨重建中促进骨形成的重要因素之一；绝经后妇女由于受雌激素和瘦素的共同影响，骨形成增强，骨吸收也增强，绝经后妇女的骨质疏松属于高转换型；绝经后妇女雌激素下降，瘦素虽促进骨形成，但雌激素在仍起关键作用，破骨仍占优势，骨吸收大于骨形成，导致绝经后妇女骨质疏松的发生。
Objective To investigate the pathogenesy of postmenopausal osteoporosis and the influence of leptin on osteoporosis. Methods Healthy woman volunteers with different ages were divided into four groups： 25 ～ 34 years old （ n = 37 ）, 35 ～ 44 years old（ n = 31 ）, 45 ～54 years old （ n =30）, postmenopausal women 55 ～65 years old （ n =40）, with no significant difference in BMI among each groups. The serum levels of leptin, follicle-stimulating hormone （ FSH ）, luteinizing, hormone （ LH ）, beta-estradiol （ E2 ）, testosterong （T）, boneglaprotein （ BGP）, alkaline phosphates （ ALP）, tatrate-resistantacid phosphatase （TRAP）, interleukin-6 （ IL-6 ）, plasma calcium （Ca） and phosphate （P） were detected. Results The serum levels of leptin and BGP increased with the age in the nonobese women group. The serum levels of FSH, IL-6 and TRAP increased while those of E2 and BMD decreased in the postmenopausal women compared with other groups. Conclusion Leptin serves as an important factor in promoting bone formation during bone rebuilding of postmenopausal women. The serum levels of leptin and BGP increase and bone formation increases. The E2 and leptin contribute to the enhancement of bone formation and bone absorption in the postmenopausal women. The level of E2 decreases but it acts more efficiently than leptin. The bone absorption is faster than bone formation, which contributes to the pathopoiesis of osteoporosis in postmenopausal women.
出处
《中国医师杂志》
CAS
2006年第1期57-59,共3页
Journal of Chinese Physician
基金
甘肃省兰州市科技计划资助项目(03-2-48)
