摘要
目的探讨尾型同源盒转录因子2(Cdx2)在肠型胃癌发生中的作用。方法采用免疫组织化学ABC法检测104例慢性浅表性胃炎、98例慢性萎缩性胃炎、112例胃黏膜肠上皮化生、106例胃黏膜不典型增生和93肠型胃癌组织中Cdx2蛋白的表达。结果Cdx2在慢性浅表性胃炎和慢性萎缩性胃炎组织中无表达,在胃黏膜肠上皮化生、胃黏膜不典型增生和肠型胃癌组织中阳性表达率分别为86.6%(97/112)、58.5%(62/106)和56.9%(53/93)。其中Cdx2在胃黏膜肠上皮化生组织中的蛋白表达阳性率显著高于胃黏膜不典型增生和肠型胃癌组织(P<0.05);在胃黏膜不典型增生与肠型胃癌组织中,Cdx2蛋白表达阳性率差异无统计学意义(P>0.05)。结论Cdx2可能为胃黏膜组织肠上皮化生病变的特异性标志物;Cdx2蛋白过表达在肠型胃癌的发生中发挥重要作用。
Objective To investigate the expression and significance of caudal type transcription factor-2 （Cdx2） in gastric mucesa at different stages of carcinogenesis. Methods By using ABC immunohistochemistry, the expression of Cdx2 was detected in the biopsy specimens of 104 cases of chronic superficial gastritis, 98 cases of chronic atrophic gastritis, 112 cases of intestinal metaplasia, 106 cases of dysplasia and 97 cases of intestinal- type gastric carcinoma. Results Cdx2 was expressed in the specimens of intestinal metaplasia with an expression rate of 86.6% （97/112 ）, significantly higher than those in dysplasia （58.5% , 62/106） and intestinal- type gastric carcinoma （56.9%, 53/93） （ both P 〈 0.01 ）, while was not expressed in the specimens of chronic superficial gastritis and chronic atrophic gastritis. No significant difference was found between the expression rate of Cdx2 was between the specimens of dysplasia and those of intestinal-type gastric carcinoma （ P 〉 0.05 ）. Conclusion Cdx2 may be a novel marker of intestinal metaplasia and may play an important role in the carcinogenesis of the intestinal-type gastric carcinoma.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2006年第4期247-249,共3页
National Medical Journal of China
基金
中国博士后基金资助项目(2004035181)
广东省自然科学基金资助项目(4009350)
关键词
胃肿瘤
化生
转录因子
Stamach neoplasms
Transcription factors
Metaplasia
