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细胞色素P450氧化还原酶的研究进展 被引量:26

Research progresses of cytochrome P450 reductase
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摘要 细胞色素P450氧化还原酶(Cytochrom e P450 Reduc-tase,CPR)是细胞色素P450药物代谢酶系中为细胞色素P450提供电子的膜蛋白,本文从电子传递、底物作用及其基因调控三方面的特性对其进行了论述,并探讨了CPR领域一些待研究的问题。 Cytochrome P450 reductase (CPR) is a kind of membrane protein which transfer electrons to cytochrome P450s in the system of drug metabolism. The structure, substrate-fuction and gene modulating of CPR is concluded, and the questions of functional mechanism of CPR are discussed in this article.
作者 程婕 杨凌
出处 《中国药理学通报》 CAS CSCD 北大核心 2006年第2期129-133,共5页 Chinese Pharmacological Bulletin
基金 国家高技术研究发展计划(863计划)重大专项基金资助项目(No111200295701)
关键词 细胞色素P450氧化还原酶 电子传递 底物作用 基因调控 细胞色素P450 cytochrome P450 reductase electron transfer substrate-function gene modulation eytochrome P450s
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