摘要
目的探讨汉丹肝乐胶囊治疗砷暴露肝损伤患者的疗效。方法20例慢性砷暴露肝损伤患者,血清学检查均排除有HBV和HCV感染,服用汉丹肝乐胶囊1.2g,3次/日,口服,疗程3个月。结果汉丹肝乐胶囊治疗后,全部患者的消化道症状均有明显改善,如腹部疼痛减轻,血清ALT水平下降(P<0.05)。治疗前肝组织活检肝细胞广泛空泡变性,灶性坏死、炎性细胞浸润及少许纤维化,治疗后肝细胞空泡变性明显恢复,灶性坏死及炎性细胞浸润不明显,没有纤维化(P<0.05)。治疗中无不良反应发生。结论汉丹肝乐胶囊治疗砷暴露肝损伤患者有效,能显著改善患者的肝组织病理病变及临床症状。
Objective To report the therapeutic effects of Han-Dan-Gan-Le （HDGL） in the treatment of As-induced liver disorders in humans. Methods Twenty chronic arsenic-exposed patients were selected based on the history of As exposure, symptoms of liver disorders, and serology excluding HBV and HCV infection. HDGL was administered at the dose of 1.2 g, tid, po for 3 months. Results After the treatment, all the patients achieved significant improvement of the gastrointestinal tract symptoms, the abdomen pain disappeared, and serum levels of ALT was decreased （P 〈 0.05）. Histology from liver biopsy samples was performed before and at the end of the 3- month treatment. Before treatment, histological examination showed widespread parenchymal cell vacuolation, focal necrosis, inflammatory cell infiltration in focal area and a few loci of fibrosis. After HDGL treatment, hepatocellular vacuolation was greatly ameliorated and focal necrosis and inflammation were not evident, and no liver fibrosis was found. The degree of hepatic histology in this before-group was significantly decreased compared with that in the ＂after- group （P 〈 0.05）. No apparent side effects were observed to stop the HDGL treatment. Conclusions This preliminary study has demonstrated that HDGL is very effective in the treatment of As-induced liver disorders, as evidenced from histopathology, appetite and other clinical improvements.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2006年第1期86-89,共4页
Chinese Jouranl of Endemiology
基金
国家自然科学基金资助项目(30471592)
关键词
砷
慢性暴露
肝损伤
汉丹肝乐胶囊
治疗
Arsenic
Chronic exposure
Liver degeneration
Han-Dan-Gan-Le
Treatment
