摘要
目的:测定肺气虚证模型大鼠血清细胞间粘附因子(ICAM1)、白介素8(IL8)的水平,探讨ICAM1、IL8在肺气虚证发病中的意义。方法:采用慢性阻塞性肺疾病(COPD)模型大鼠的造模方法建立肺气虚证大鼠模型,经鼻腔注入肺炎克雷伯杆菌反复感染造模。采用ELISA测定血清ICAM1、IL8的水平。结果:肺气虚证模型组ICAM1、IL8水平均显著高于正常组(P<0.01)。结论:ICAM1、IL8可能趋化和介导中性粒细胞参与了肺气虚证慢性气道炎症反应,在肺气虚证的发病机制中有着重要意义。
Objective： To observe the effects of the changes of cytokine on the escherihia colic pneumonia in order to provide basis for the explanation of the mechanisms of pulmonary qi deficiency syndrome. Method： According to the principle of random,24 Wistar rats （male） were divided into control group （CG）, model group （MG）, model group was established by repeatedly intranasal infecting of klebsieUa pneumoniae twice a week. ICAM-1 and IL-8 in serum of two groups were measured by ELISA. Result： The level of serum ICAM-1 and IL-8 of MG was higher than that of CG significantly （ P 〈 0.01 ）.Conclusion： ICAM-1, IL-8 might involve in the pathology of pulmonary qi deficiency and play an impotant role in the pathogenitic process of pulmonary qi deficiency syndrome by activating poly morpho nuclear leukocyte.
出处
《光明中医》
2005年第6期38-40,共3页
GUANGMING JOURNAL OF CHINESE MEDICINE
基金
安徽省自然科学基金资助项目(NO:010431006)
