摘要
报道了多次口灌呋喃唑酮(60 mg/kg,连续3 d,每天1次)在草鱼体内血浆、肌肉、肝脏和肾脏中的消除与残留研究。采用高效液相色谱法(HPLC)检测用药后不同时间各组织中药物浓度,M ILLEMNIUM32工作站处理原始数据,MCPKP药代动力学软件处理药时数据。结果表明:多次口灌呋喃唑酮在草鱼体内的药时数据符合一级速率吸收一室开放模型,其主要药动学参数为:AUC 2.3182μg.h/m l,Cmax 0.850μg/m l,Ka 0.5515 h-1,K 0.0936 h-1,T1/2ka1.2565h,T1/2k7.4308h,Tp 2.8732 h,药物在血浆、肌肉、肝脏、肾脏中消除时间分别为:72 h、15 d、20 d、20 d。
Residues of furazolidone in tissues （plasma, muscle, liver and kidney ） in grass carp Ctenopharyngodon idelles administrated multiple-orally were measured using high performance liquid chromatography （HPLC） and processed at MILLEMNIUM^32 work station. The plasma concentration-time data was analyzed with MCPKP practical pharmacokinetics software. The results showed that the concentration-time curve of furazolidone in grass carp blood was in accordance with one-compartment open model with first order absorption. The main parameters were： AUC 2. 3182 μg · h/ml,Cmax 0. 850 μg/ml, Ka 0. 5515 h^-1 , K 0. 0936 h^-1, T1/2ka 1. 2565 h, T1/2k 7.4308 h, Tp 2. 8732 h. It took 3 d, 15 d, 20 d and 20 d for the depletion of furazolidone from plasma, muscle, liver and kidney, respectively.
出处
《水产科学》
CAS
北大核心
2006年第2期75-78,共4页
Fisheries Science
基金
农业部重点资助项目(渔95-B-00-01)
湖南省教育厅科研基金资助项目(03C269)
关键词
呋晡唑酮
草鱼
组织残留
消除
furazolidone
grass carp （Ctenopharyngodon idellus）
tissue residues
depletion
