摘要
背景与目的 化疗是中晚期非小细胞肺癌常用的治疗方法，但化疗有效率较低，约20％～50％，而且存在较为严重的副作用。为提高疗效，改善患者生活质量，降低毒副反应，本研究对康莱特联合化疗和单纯化疗治疗中晚期非小细胞肺癌的疗效、毒副反应及对生存质量的影响进行了比较。方法 将100例患者随机分成两组。单纯化疗组（对照组）50例，采用GP方案：吉西他滨1000mg／m^3，第1、8天，顺铂80mg／m^3，第2天，3周为一周期。康莱特联合化疗组（康莱特组）50例，化疗方案同对照组，于每周期化疗第一天开始静脉滴注10％康莱特注射液200ml，连用10天。两周期治疗结束后对其近期疗效、毒副反应及生存质量进行评价。结果 康莱特组有效率为52％，对照组为32％，两组比较有显著性差异（X^2-4．04，P〈0．05）。两组疗后的生存质量有显著性差异（t=2．8，P〈0．05）。康莱特组的不良反应发生率低于对照组，且发生的程度较轻。结论 康莱特联合化疗能提高有效率，降低不良反应，改善患者的生存质量。
Background and objective Chemotherapy is a common way to treat advanced non-small cell lung cancer （NSCLC）. The response rate of chemotherapy is only 20 %-50%, and the side effects are serious. To improve efficacy and quality of life and to reduce side effects of chemotherapy become main tasks of clinical researches. The aim of this study is to evaluate GP regimen alone and GP regimen combined with Kanglaite on the efficacy, side effects and the improvement of quality of life in the treatment of advanced NSCLC. Methods Randomly fifty patients with NSCLC in stage Ⅲ and Ⅳ were treated by GP regimen combining with Kanglaite, and fifty patients were treated with GP regimen alone. Kanglaite was used on the first day of each chemotherapy cycle for consecutive 10 days, and the dosage was 200 ml/d. GP regimen included gemcitabine 1000 mg/m^2 on 1st and 8th days and cisplatin 80 mg/m^2 on 2nd day. The treatment was repeated every three weeks. The efficacy, side effect and quality of life were compared after two cycles of chemotherapy. Results Response rate was 52% in combining group and 32% in control group. The rates were different between the two groups （X^2 =4.04, P〈0.05）. Quality of life in combining group was significantly higher than that in control ：group after treatment （t=2.8, P〈0.05）. The incidence of side effects in combining group was lower than that in control group, and the degree was also slighter. Conclusion Kanglaite in combination with GP regimen can be used for the treatment of advanced NSCLC. It can improve efficacy and the quality of life, and reduce the side effect of chemotherapy.
出处
《中国肺癌杂志》
CAS
2006年第1期74-77,共4页
Chinese Journal of Lung Cancer
关键词
康莱特
联合化疗
非小细胞肺癌
Kanglaite Comprehensive chemotherapy Non-small cell lung cancer
