摘要
非酒精性脂肪性肝炎(Nonalcoholic steatohepatitis,NASH)是由肥胖、Ⅱ型糖尿病、高脂血症、快速减肥、长期全肠道外营养(TPN)、空-回肠旁路手术及药物等多种危险因素引起的一种较新的临床病理综合征。NASH发病机制非常复杂,许多前期研究虽然获得了初步资料,但对NASH的发病机制还没有十分明确。目前认为,FFA蓄积、氧化应激、胰岛耐受、P450(CYP2E1或CYP4A)、瘦素、Kupffer细胞及细胞因子等在NASH的发病中起重要作用。
Nonalcoholic steatohepatitis（NASH） is a newer clinicopathological syndrome which is associated with many risk factors,such as obesity,type Ⅱ diabetes mellitus, hypertriglyceridemia, rapid weight loss, total parenteral nutritiontpn（TPN） ,jejunoileal bypass surgery（JIB） and drug et al. The pathogenesis of NASH is complicated. Despite preliminary data from numbers of pilot studies, no established theory can be offered to N ASH. Several studies have demonstrated that free fatty acid （FFA）, oxidative stress, insulin resistance, P450（ CYP2EI or CYP4A） ,leptin, Kupffer ceils and cytokines may play a role in development of NASH.
出处
《安徽医药》
CAS
2006年第2期81-84,共4页
Anhui Medical and Pharmaceutical Journal
关键词
病因
病理
发病机制
非酒精性脂肪性肝炎
etiological factor
histopathology
pathogenesis
nonalco：holic steatohepatitis
