摘要
基于Pennes传热方程,从理论上分析了光动力治疗中激光作用所引起的组织温升的变化.结果表明,激光照射在生物组织内形成热源,该热源在一维生物组织空间引起组织的温升一般随时间呈指数形式增大,随激光照射处的距离呈指数减少.激光照射生物组织产生热效应,存在一个最小阈值光剂量,仅当照射的激光剂量大于阈值光剂量时,才能产生热效应.阈值光剂量大小由生物组织的光学参量和热物性参量决定,并随激光照射处的距离呈指数增加.
Temperature distribution in the bio-tissue during PDT is theoretical analyzed based on the Pennes＇ bio-heat transfer equations. The study indicated that Laser heat source can be formed in bio-tissue during laser irradiation which result in temperature rising in one-dimensional space. The temperature in biological tissue increases in exponent with time and decreases in exponent with the distance from laser irradiation area. There is minimal light dosage threshold during the optical-thermal interaction between laser and biological tissue. When light dosage below the critical threshold, laser irradiating will not produce thermal effect. The threshold, which depends on optical parameter and heat parameter of biotissue, increases in exponent with the distance from laser irradiating area.
出处
《光子学报》
EI
CAS
CSCD
北大核心
2006年第2期269-273,共5页
Acta Photonica Sinica
基金
国家自然科学基金(60178034)
湖北省教育厅自然科学基金(2001B45001)资助
关键词
光动力疗法
光剂量
光热效应
理论分析
Photodynamic therapy
Light dosage
Optical-thermal interaction effect
Theoretic analysis
