摘要
目的:探讨慢性心力衰竭(CHF)患者血清可溶性血管细胞粘附分子-1(sVCAM-1)、肿瘤坏死因子α(TNF-α)浓度的变化并探讨其临床意义。方法:选取CHF患者61例,正常对照组25例。采用ELISA法测定其血清sVCAM-1浓度,采用放射免疫分析法测定其血清TNF-α浓度。结果:与正常对照组相比,CHF组血清sVCAM-1、TNF-α水平显著升高(P<0.01),sVCAM-1、TNF-α水平随心功能不全的加重而明显升高。各病因组之间sVCAM-1、TNF-α水平比较无显著性差异(P>0.05)。血清sVCAM-1与血清TNF-α呈正相关(r=0.282,P<0.01)。结论:CHF患者血清sVCAM-1、TNF-α水平明显升高,并与CHF严重程度有关,提示sVCAM-1、TNF-α可能在CHF的发病机制中起了重要作用。
Objective： To explore the alteration and clinical significance of serum soluble vascular cell adhesion molecule- 1 （sVCAM- 1）and tumor necrosis factor-alpha （TNF-α） in patients with chronic heart failure（CHF）. Methods： The study included 61 patients with CHF and 25 normal subjects. The serum sVCAM-1 level was measured by enzyme linked immunoassay and TNF-α was detected by radioimmunoassay, Results： The serums sVCAM-1 level and TNF-α were significantly higher in the patients with CHF than those in the normal subjects （ P 〈 0.01 ）. The serums sVCAM-1 level and TNF -α in the patients with CHF were significantly increased with a decrease in heart function. There were no obvious differences in sVCAM-1 and TNF-α in different disease groups. The serums sVCAM-1 level was positively correlated with the serum TNF-α level（ r = 0. 268, P 〈 0.05 ）. Conclusion：The serum sVCAM- 1 and TNF-α increase significantly in the patients with CHF and the increases are closely related with severity of CHF, suggesting that the sVCAM-1 and TNF-α may play an important role in the development of CHF.
出处
《黑龙江医药科学》
2006年第1期26-27,共2页
Heilongjiang Medicine and Pharmacy
基金
佳木斯大学研究生创新科研基金资助项目编号:YJSCX2005-007JD
关键词
慢性心力衰竭
可溶性血管细胞粘附分子
肿瘤坏死因子
chronic heart failure
soluble vascular cell adhesion molecule-1
tumor necrosis factoralpha
