摘要
目的探讨白介素-4(IL-4)及白介素-8(IL-8)在慢性阻塞性肺疾病(COPD)发病机制中的作用。方法搜集28例COPD急性加重期患者,25例COPD缓解期患者和30例健康者的静脉血,离心后取血清,采用酶联免疫法(ELISA)测定其中IL-4及IL-8水平,同时对COPD患者常规测定动脉血PO2、PCO 2以及一秒钟用力呼气容积占预计值百分比(FEV1%),并把它与IL-4及IL-8进行相关性比较。结果COPD急性加重期患者血清IL-4及IL-8水平明显高于缓解期及健康对照组,缓解期明显高于对照组,差异有显著性(P<0.05),COPD急性加重期血中IL-4及IL-8含量与PO 2、FEV1%呈负相关,与PCO 2呈正相关。结论IL-4及IL-8参与了COPD气道炎症反应,IL-4及IL-8检测对慢性阻塞性肺疾病诊断和预后判断具有积极作用。
Objective To evaluate the implication of IL - 4 and IL 8 in chronic obstructive pulmonary disease （COPD）. Methods Serum levels of IL - 4 and IL - 8 were determined by ELISA in 28 patients with acutely exacerbated COPD, 25 patients with stable COPD, and 30 healthy subjects were served as control. PO2, PCO2 and FEV1 % were assayed also, and the relationship among these parameters was statistically analyzed. Results The serum IL- 4 and IL- 8 levels in acute exacerbated COPD were obviously higher than those in stable COPD patients as well as the healthy controls; the stable COPD patients were obviously higher than that of the healthy controls. Furthermore, among the acute exacerbated COPD patients the serum IL - 4 and IL 8 levels of patients with smoking habit were significantly higher than of the non smokers. The serum IL - 4 and IL 8 levels of acutely exacerbated COPD patients were negatively correlated with the PO2 and FEV1% ,and positively correlated with PCO2. Conclusion Serum IL-4 and IL - 8 may participate in the airway inflammatory process of COPD.
出处
《实用预防医学》
CAS
2006年第1期66-67,共2页
Practical Preventive Medicine
