摘要
通过观察ＳＤ大鼠肝细胞的超微结构改变，以及与血药浓度的关系，旨在研究环孢素Ａ（ＣｓＡ）所致肝脏毒性作用的机理。给药后肝细胞早期以线粒体、粗面内质网、滑面内质网、细胞核的改变为主，肝细胞及毛细胆管内胆汁瘀积，溶酶体及微体增多集中于细胞核周围；晚期为以纤维细胞及枯否细胞增生为主的恢复样改变，溶酶体及微体集中于细胞膜附近，实验结果提示：ＣｓＡ的肝毒性作用具有明显的时相效应，并与血药浓度密切相关；保肝治疗可减轻肝毒性，且易于恢复。
The ultrastructural changes in CsA-induced hepatotoxicity were studied in SD rats.Vacuolar degeneration of liver cells,proliferation of rough surface endoplasmic reticulum and degranulation; mitochondrial swelling,matrical rarefaction,crista framentatism,Obliteration and blurred configuration; hyperplasia of lysosome and microsome were noticed.It was noted that CsA-induced hepatotoxicity had a noticeable time-phase effect and was closely related to the CsA blood level.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1996年第2期85-87,共3页
Chinese Journal of Urology
关键词
环孢素A
药物副作用
肝毒性
Cyclosporine A,Animals.Laboratory,Hepatotoxicity
