摘要
本研究旨在中国边线性碘缺乏地区上海市探讨孕妇及新生儿垂体－甲状腺轴功能。结果表明：（1）新生儿促甲状腺激素（TSH）水平＞5mIu／L者占61．0％．＞10mIu／L者占23．0％。孕妇TSH水平＞5mIu／L者仅占5．5％，但新生儿及孕妇TSH水平却呈平行改变。新生儿TSH水平与其母亲尿碘水平呈显著负相关（r＝－0．48．P＜0．01）。（2）新生儿游离甲状腺素（FT4）水平与其自身TSH水平呈显著负相关（r＝－0．50．P＜0．01），29．8％的新生儿FT4水平低于正常。（3）孕妇三碘甲状腺原氨酸（T3）／甲状腺素（T4）比值高于正常，孕妇T3／T4；比值的增高与新生儿T3／T4比值及TSH水平的增高呈平行改变．孕妇T3水平与其自身TSH水平呈显著正相关（r＝0．52P＜0．01）。作者认为：该地区碘缺乏高危人群孕妇及新生儿的垂体－甲状腺轴功能已受到一定影响．应实施碘干予措施。
The present study was to explore pituitary - thyroid axis function of pregnant women and neonates in Shanghai, a marginal iodine deficiency area. The results showed: l. The percentage of neonates with thyroid stimulating hormone (TSH) levels higher than5 mlu/L was 61.0% .and higher than 10mlu/L was 23. 0%. The percentage of pregnant women with TSH levels higher than 5 mlu/L was only 5. 5%. The changes of TSH levels of pregnant women and neonates were parallel.The maternal urinary iodine values were inversely related to the TSH levels of the neonates (r = 0. 48. P <0.01), 2. The plasma free thyroxine (FT4 )levels were inversely related to the TSH levels in the neonates (r =-0. 50. P < 0. 01). The percentage of neonates triiodothyronine (T3 ) / thyroxine (T4) ratio of the pregnant women was higher than normal. The increase of T3/T4 ratio of pregnant women was associated with T3 /T4ratio and TSH levels of neonates. The plasma T3 levels were correlated with the TSH levels in the pregnant women (r = 0.52. P <0.01). We considered that the pituitary - thyroid function of the pregnant women and neonates was influenced and iodine replacement intervention should be conducted in thisarea.
出处
《贵州医药》
CAS
1996年第1期7-9,共3页
Guizhou Medical Journal
关键词
边缘性
碘缺乏区
孕妇
新生儿
垂体
甲状腺
Iodine deficiency pituitary Thyroid Neonates Pregnant women
