摘要
目的:了解肺炎克雷伯菌在临床不同标本中的耐药性特点及差异。方法:对临床各类标本进行常规微生物培养及药敏试验。结果:共检出肺炎克雷伯菌315株,ESBLs菌株47株。在痰中检出242株、中段尿31株、血15株、咽拭子10株、分泌物8株及脓液9株。在15种抗菌药物的药敏结果中,耐药率>70%的抗生素有2种,亚胺配南耐药率最低(5.7%)。产ESBLs菌株对多种抗菌药物的耐药率显著高于非产ESBLs菌株(P<0.05)。同一抗生素对于不同标本分离的肺炎克雷伯菌显示出不同的敏感性。结论:临床医生选用抗生素时,应综合考虑各种因素。
Objective: To investigate the clinical distribution of the infection by K. pneumoniae and the antimicrobial resistance. Methods: Bacteria were detected using bio Merieux VITTEK-2 system. Results: A total of 315 strains of K. pneumoniae, and ESBLs producing strains were 47. Resistant rates over 70% added up to 2 among the 15 tested antimicrobial agents. The lowest of resistant rates was imipenem (5.7%). Resistant rates of ESBLs producing strains were much higher than ESBLs nonproducing strain (P 〈 0. 05 ). The difference of sensitivety to a antibiotics of K. pneumonine was analyzed for different site of infection. Conclusion: More attention to the surveillance of antimicrobial resistance of K. pneumoniae in clinics and preventing transmission or epidemic of their resistant strains should be given.
出处
《江苏大学学报(医学版)》
CAS
2006年第1期56-58,共3页
Journal of Jiangsu University:Medicine Edition
关键词
肺炎克雷伯菌
抗生素
耐药性
K. pneumoniae
Antibiotics
Drug-resistantce