脑梗死患者急性期血清血红素氧合酶-1、非结合胆红素含量变化及临床意义被引量：7

Contents change and clinical significance of serum heme oxygenase-1 and unconjugated bilirubin in patient with acute cerebral infarction

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摘要目的探讨脑梗死患者急性期血清血红素氧合酶-1(HO-1)和非结合胆红素(UCB)含量的变化及临床意义。方法用酶联免疫吸附(ELISA)法及钒酸盐氧化法测定急性脑梗死(ACI)患者发病第1d、3d、6d及正常对照组的空腹血清HO-1及UCB浓度,并进行比较分析。结果ACI组发病第1d、3d、6d血清HO-1及UCB浓度依序下降。发病第1d ACI患者血清HO-1浓度和同期血清UCB浓度呈正相关(r=0·645,P<0·05);脑梗死体积和发病第1d血清HO-1浓度呈正相关(r=0·358,P<0·05),脑梗死体积和发病第3d、第6d血清UCB浓度呈负相关(r=-0·335,r=-0·267,均P<0·05)。结论HO-1的升高可能是机体对脑缺血损伤的防御反应,UCB可能在脑梗死的发病过程中具有一定的保护作用。 Objective To speculate the contents changes and clinical significance of heine oxygenase-1 （ HO-1 ） and unconjugated bilirubin （UCB） in the patients with acute cerebral infarction. Methods HO-1 and UCB in blood serum were measured in these patients with acute cerebral infarction（ACI） and control group at one day, third day, and sixth day after the onset by ELISA and oxidation of vanadate. Results The content of HO-1 and UCB in serum decreased step by step at the first day, third day, and sixth day after the onset. The level of HO-1 displayed a positive correlation with the UCB in serum in the first day after the onset （ r = 0. 645, P 〈 0. 05 ） ; The infarct volume was in positive correlation with the level of HO-I in the first day after the onset （ r = 0.358, P 〈 0. 05 ） ; The infarct volume were in negative correlation with the level of UCB in the third day and sixth day （ r = - 0. 335, P 〈 0. 05 ; r = - 0. 267, P 〈 0. 05 ）. Conclusions The upregnlation of Heine oxygenase-1 may be a sort of natural defensive reaction against ischemic injury. UCB maybe play the role of protective function for patients with cerebral infarcts.

作者李海鹏肖波陈继华杨国帅杨期明黄仁彬熊波

机构地区湖南郴州市第一人民医院神经内科中南大学湘雅医院神经内科

出处《临床神经病学杂志》 CAS 北大核心 2006年第1期25-27,共3页 Journal of Clinical Neurology

关键词脑梗死血红素氧合酶-1 非结合胆红素 cerebral infarction heme oxygenase-1 unconjugated bilirubin

分类号 R743.33 [医药卫生—神经病学与精神病学]

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