摘要
目的:对照电针和西比灵(盐酸氟桂利嗪)的效应,探讨电针改善椎-基底动脉供血不足(VBI)所致内耳微循环障碍的机理及电针对前庭-眼反射(VOR)的影响。方法:组织硬化剂—775注射液注射致家兔左侧颈椎横突软组织建立椎动脉型颈椎病(VCS)模型,采用直线加速度(LA)和水平旋转(HR)诱发眼震电图(ENG)、经颅多谱勒(TCD)、激光多谱勒血流计(LDF)和血液流变学,检测VBI家兔NEG频率、基底动脉(BA)血流速度、内耳血流量(IEBF)、血液粘度和细胞流变性变化。结果:模型组ENG频率、BA血流速度和IEBF显著降低,全血中、低切变率粘度和红细胞聚集指数(EDI)显著增高。西比灵可显著降低全血粘度和EDI,加快BA收缩期血流速度(Vs),但对舒张期血流速度(Vd)和平均血流速度(Vm)无明显作用。电针不能降低血液粘度和EDI无明显作用,但改善IEBF和LA诱发的ENG作用较西比灵显著,并有增快Vs、Vd和Vm的趋势,电针和西比灵对HR诱发的ENG均无改善作用。结论:VBI所致内耳微循环障碍可引起前庭和水平半规管功能障碍,电针可能通过神经-体液调节改善VBI,并可能主要通过增强内耳微循环局部调节改善内耳血供,恢复前庭囊斑对LA的敏感性。电针效应优于西比灵。VBI模型前庭器官内血流分配及前庭信号转导可能存在复杂的机制,有待深入研究。
Aim： To investigate the mechanism of EA improving the obstruction of inner ear microcirculation and the effect on the vestibuloocular reflex（VOR）by comparing the effects of electroacupunctrue（EA）with sibeline（ flunarizine hydrochloride）on vertebrobasilar insufficiency（VBI）. Methods： Injected with sclerosant-775 injection into the solt tissue on the left side of cervical vertebral transverse processes of rabbits to set up the vertebral artery type of cervical spondylosis（VCS） models. Electronystagrnography （ENG） induced by linear acceleration （LA） and horizontal rotation （ HR ）, the transcranial Doppler （TCD）, laser Doppler flowrnetry （LDF） and hemorheology were used to measure changes of the frequencies of nystagmus, the hemodynamics in the basilar artery（BA）,inner ear blood flow（IEBF） and blood viseosity in VBI rabbits. Results： The frequencies of ENG, the velocity of blood flow in BA and IEBF decreased obviously ,and whole blood middle shere viseosity , whole blood lower shere viseosity and erythrocyte distortion index （ EDI） increased significantly in the model group. Sibeline could reduce whole blood viseosity and EDI ,and increased the systolic phase velocity（Vs） of blood flow in BA, but had no effect on disatolic phase velocity（Vd）and mean velocity（Vm）. EA could not reduce the viseosity of blood and EDI, but had more significent effects on improving IEBF and ENG induced by LA than those of sibeline, and had the tendency of increasing Vs, Vd and Vm. EA and sibeline had no effect on improving ENG induced by HR. Conclusion： Inner ear microcirculation obstruction caused by VBI can induce dysfunctions of vestibule cystmacula and horizontal semicircular canals . EA may depend upon the neurohumoral regulation to improve VBI , and ameliorate inner ear blood supply obstruction by enhancing mech- anism of local adjusting for microcirculation in the inner ear to recover vestibular cystmacula irritability for LA chiefly. There exist complicated mechanism that EA adjusts blood flow distribution and vestibular signal transduction in vestibular organ in VBI model likely ,and remain to be researched deeply.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2006年第1期99-104,共6页
Chinese Journal of Applied Physiology
基金
四川省教育厅国家自然科学基金预研项目(01LC11)
关键词
椎-基底动脉供血不足
眩晕
前庭
眼震
血流速度
微循环
血液流变学
电针
vertebrobasilar insufficiency
vertigo
vestibule
nystagmus
microcirculation
blood flow velocity
electroacupuncture
