摘要
目的 探讨参附注射液在肝移植术后应用的疗效。方法 2004年1月-2005年3月实施的同种异体原位肝移植手术病例30例，随机均分为2组，对照组予以常规补液、对症支持等治疗，治疗组在此基础上加用参附注射液100ml静注，两组进行对比分析研究。结果 两组患者在治疗前平均动脉压（MAP）、心率（HR）及血乳酸、IL-6、IL-8、TNF-α差异无显著性（P〉0．05）。参附注射液治疗结束后120min，治疗组MAP从53．21±8．52mmHg增至75．62±7．58mmHg，HR从115.3±13.2／min降至90．1±7，2／min，血乳酸、IL-6、IL-8和TNF-α分别从9．82±3．96mmol／L、89.02±43.75pg／ml、58．24±33．61pg／ml和42．33±28．15pg／ml降至4．31±2．1lmmol／L、30．08±25．12pg／ml、29．83±20．05pg／ml和24．52±15．61pg／ml，与对照组相比有显著性差异（P〈0．05）。结论 肝移植术后用参附注射液治疗的患者平均动脉压和心率均有所改善，并降低了血乳酸和炎症因子水平，对循环和缺血再灌注损伤有较好的改善作用。
Objective To study the therapeutic action of SHENFU （ginseng-aconite） injection on post-operation of liver transplantation. Methods From Jan. 2004 to Mar. 2005, 30 cases underwent orthotopic liver allotransplantation were divided into two groups randomly. The patients in control group received routine transfusion, while the patients in SHENFU injection group, besides the routine transfusion, received SHENFU injection as well. Results 120 minutes after the SHENFU treatment, the mean arterial pressure （MAP） of the patients was raised from 53. 21±28. 52mmHg to 75.62±7. 58mmHg, meanwhile the heart rate （HR） declined from 115. 3±13. 2/min to 90. 1±7. 2/min. At the same time, the contents of lactic acid, IL-6, IL-8 and TNF-α in the patients also declined from 9. 82±3. 96mmnol/L, 89. 02±43. 75pg/ml, 58. 24±33. 61 pg/ml and 42. 33±28. 15pg/ml to 4. 31±2. 11mmol/L, 30. 08±25. 12pg/ml, 29. 83± 20. 05pg/ml and 24. 52± 15.61pg/ml, respectively. Compared with the control group, there existed significant differences （P〈0. 05）. Conclusions The SHENFU injection, when be used on to the post-operative patients of liver transplantation, may improve the patients MAP and HR, decline the contents of lactic acid and inflammatory factors, and alleviate the injury caused by post-operative circulation and ischemic reperfusion.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2006年第2期152-153,共2页
Medical Journal of Chinese People's Liberation Army
基金
卫生部999中药注射剂科学研究基金
关键词
参附注射液
肝移植
再灌注损伤
Shenfu injection
liver transplantation
reperfusion injury
