摘要
为了评价免疫分型在急性白血病(AL)分型中的科学意义,应用形态学分型、直接免疫荧光标记流式细胞仪检测免疫分型对68例AL进行了分析。结果表明:形态学与免疫学检查符合率为94.1%,有4例形态学误诊被免疫分型纠正;髓系中较特异抗原为CD13、CD33,AML-M3多为CD34低表达,HLA-DR阴性,AML-M4、M5易有CD14表达,髓系中易见淋系相关抗原表达,常见为CD7;淋系中亦可合并髓系抗原表达。结论:免疫分型可提高AL的诊断分型准确性,特殊类型AL如急性未分化性白血病(AUL)、AML-M等的诊断必须依赖免疫分型。
To evaluate the significance of immunologic classification for typing of acute leukemia （AL）. 68 cases of AL were classified by morphologic and immunologic typings. The results showed that the consistency rate was 94.1% between morphology and immunology, and 4 morphologic misdiagnosed cases were corrected by immunology; CDI3 and CD33 were special myeloid lineage-associated antigens; AML-M3 was often CD34 low-expressed and HLA-DR- negative; CD14 was often expressed in AML-M4 and Ms; lymphoid lineage-associated antigens （CD7） were easily found in ANLL, and myeloid lineage-associated antigens were also found in ALL. In conclusion, immunologic classification can improve the accuracy in acute leukemia diagnosis. The diagnosis of some special AL, such as acute unidentified leukemia （AUL）, AML-M0 and so on, must rely on immunologic classification.
出处
《中国实验血液学杂志》
CAS
CSCD
2006年第1期39-41,共3页
Journal of Experimental Hematology
关键词
急性白血病
形态学
免疫分型
免疫表型
acute leukemia
morphologic classification
immunologic classification
immunologic phenotype
