摘要
细胞因子信号转导抑制因子3(SOCS-3)是白细胞介素6(IL-6)信号转导的负调节因子。研究发现血清IL-6水平与胰岛素抵抗相关,而且可以诱导SOCS-3的基因转录。因此,SOCS-3mRNA的高表达可能是IL-6介导胰岛素抵抗发生的机制之一。
[ Summary ] Suppressor of cytokine signaling (SOCS) -3 is a negative regulator of interleukin (IL) -6 signal transduction. The results showed that IL-6 was not only correlated with insulin resistance but also capable to induce the expression of SOCS-3. Thus the high expression of SOCS-3 mRNA may contribute to one of the mechanisms of IL-6 dependent insulin resistance.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2006年第1期77-78,共2页
Chinese Journal of Endocrinology and Metabolism