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细胞因子信号转导抑制因子3与白细胞介素6、胰岛素抵抗的关系 被引量:7

Suppressor of cytokine signaling-3, interleukin-6 and insulin resistance
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摘要 细胞因子信号转导抑制因子3(SOCS-3)是白细胞介素6(IL-6)信号转导的负调节因子。研究发现血清IL-6水平与胰岛素抵抗相关,而且可以诱导SOCS-3的基因转录。因此,SOCS-3mRNA的高表达可能是IL-6介导胰岛素抵抗发生的机制之一。 [ Summary ] Suppressor of cytokine signaling (SOCS) -3 is a negative regulator of interleukin (IL) -6 signal transduction. The results showed that IL-6 was not only correlated with insulin resistance but also capable to induce the expression of SOCS-3. Thus the high expression of SOCS-3 mRNA may contribute to one of the mechanisms of IL-6 dependent insulin resistance.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2006年第1期77-78,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 细胞因子信号转导抑制因子3 白细胞介素6 胰岛素抵抗 Suppressor of cytokine signaling-3 Interleukin-6 Insulin resistance
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