摘要
目的比较^(18)F-脱氧葡萄糖(FDG)与^(11)C-蛋氨酸(MET)PET 显像在神经上皮性肿瘤术前分级中的价值及与细胞增殖指标 Ki67的相关性。方法 39例经病理检查证实的神经上皮性肿瘤患者分别行^(18)F-FDG、^(11)C-MET PET 检查,均进行视觉分析和半定量分析,并与病理分级和 Ki67标记指数(LI)比较,进行统计学分析。结果视觉分级:23例高级别肿瘤患者中有22例呈^(18)F-FDG 高代谢,16例低级别肿瘤患者中有14例呈^(18)F-FDG 中、低代谢;39例患者中除1例低级别肿瘤表现为^(11)C-MET 低代谢外,其余均为^(11)C-MET 高代谢。半定量分析:^(18)F-FDG 结果显示,除Ⅰ级与Ⅱ级肿瘤间无统计学差异外,其余各级间差异均有显著性(P<0.05);^(11)C-MET 结果显示,只有Ⅱ级与Ⅳ级肿瘤间差异有显著性(P<0.01),其余各级间均无统计学差异。^(18)F-FDG 与^(11)C-MET 的摄取均与 Ki67 LI 呈显著正相关,^(11)C-MET 的相关性强于^(18)F-FDG。且Ⅱ、Ⅲ级肿瘤内^(11)C-MET 的摄取与 Ki67 LI 亦相关,而^(18)F-FDG在各级肿瘤内与 Ki67 LI 均无相关性。结论 ^(18)F-FDG 的视觉及半定量分级均优于^(11)C-MET;^(11)C-MET 有助于低级别肿瘤的检出和边界描绘,且^(11)C-MET 的代谢活性更能体现肿瘤细胞的增殖特性。
Objective To compare the value of lSF-fluorodeoxyglucose （FDG） and ^11C-methionine （MET） PET in the preoperative grading of neuroepithelioma and the correlation with Ki67. Methods Thirty-nine cases with neuroepithelioma proved by pathology were examined with ^18F-FDG and ^11C-MET PET preoperatrively. Both images were analysed visually and semiquantitatively, and also correlated the pathologic grading with Ki67 labelling index （LI）. Results ①Visual analysis： 22/23 high-grade tumors showed ISF-FDG hypermetabolism and 14/16 low-grade tumors showed ISF-FDG moderate-metabolism or hypometabolism. All cases except 1 low-grade tumor case showed ^11C-MET hypermetabolism. ②Semiquantitative analysis ^18F-FDG PET showed significant differences between various grades （ P 〈 0.05 ）, except between grade Ⅰ and Ⅱ tumors. ^11C-MET PET showed differences only between grade Ⅱ and Ⅳ tumors（P 〈0.01 ） not in others. Both ^18F-FDG and ^11C-MET showed positive correlation with Ki67 LI, but in subgroups of grade Ⅱ and Ⅲ tumors only IIC-MET showed correlation with Ki67 LI. Conclusions Visual and semiquantitative grading with is F-FDG in neuroepithelioma is better than that with ^11C-MET. ^11C-MET is of great value in detecting low-rade tumors and delineating its boundary. The uptake of ^11C-MET denotes more significantly with the proliferation activity than ^18F-FDG.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2006年第1期8-12,共5页
Chinese Journal of Nuclear Medicine
