摘要
目的对急性重症脑血管疾病并发全身炎症反应综合征(SIRS)患者进行中药(清热止咳冲剂)干预,观察用药前后血清TNF-α、IL-6和IL-10的动态变化,并探讨其临床意义。方法用放射免疫法对20例急性重症脑血管疾病并发SIRS患者用药前、后(第5、14天)血液中TNF-α、IL-6、IL-10进行检测。结果血清TNF-α含量在用药前(发病48 h内)较正常对照组显著增高(P<0.05),用药前与用药后第5天、14天比较无显著差异(P>0.05)。IL-6含量在用药前(发病48 h内)、用药后5天、14天与正常对照组比较均无显著差异(P>0.05)。IL-10含量在用药前(发病48 h内)较正常对照组显著增高(P<0.05),用药后5天、14天与用药前比较显著增高(P<0.05)。结论急性重症脑血管病患者发病48 h内血清TNF-α较正常对照组显著增高,用药干预前、后无显著性差异。IL-6含量在发病48 h内与正常对照组及用药前、后均无显著差异。IL-10含量在发病48 h内较正常对照组显著增高,用药后5天、14天比用药前显著增高。TNF-α、IL-6、IL-10水平的变化对急性重症脑血管疾病并发SIRS早期预测和干预可能具有重要意义。
Objective To study the change of serum TNF-α, IL-6, IL-10 in patients who suffer from acute severe cerebralvescular disease complicated with systemic inflammatory response syndrome before and after treatment of qingrezhike powder preparation for infusion. Methods Using radioimmu noassay （RIA） method, serum TNF-α, IL-6, IL-10 levels were measured in 20 patients with acute severe cerebralvescular disease complicated with systemic inflammatory response syndrome and the results in different time before, after the treatment, 30 persons as healthy controls. Results Before treatment, serum TNF-α level was significantly higher in the patients than that in healthy controls, hut there was no significant difference before and after the treatment （P 2〉 0.05）. Serum IL-6 level was no significant differences in different time. Serum IL-10 level was significantly higher in patients after onset than healthy controls （P 〈 0.05）. After treatment with the qingrezhike powder preparation for infusion, IL-10 level was significantly higher in patients than that before treatment （P 〈0.05）, Conclusions Serum TNF- a and IL- 10 levels were significantly higher in the patients who suffer form acute severe cerebralvescular disease complicated with SIRS. But serum IL-6 level was no difference from the healthy controls. After the treatment with qingrezhike powder preparation, Serum IL- 10 level was significantly higher in patients, Cytokines （TNF-α, IL-6, IL-10） may play an important role in acute severe cerebralvescular disease complicated with systemic inflammatory response syndrome, Their changes may be helpful in understanding of pathogenesis and treatment effect in acute severe cerebralvescular disease complicated with systemic inflammatory ＇response syndrome.
出处
《神经疾病与精神卫生》
2005年第6期417-419,共3页
Journal of Neuroscience and Mental Health
关键词
脑血管疾病
系统性炎症反应综合征
多脏器功能紊乱综合征
细胞因子
清热止咳合剂
Cerebral vescular disease Systemic inflammatory response syndrome Multi-organ dysfunction syndrome Sytokines Qingrezhike powder preparation for infusion
