摘要
目的:探讨血管内皮细胞生长因子(VEGF)和肝细胞生长因子(HGF)与糖尿病血管合并症的关系。方法:用ELISA法测定126例2型糖尿病和30例正常人(对照组)血清VEGF和HGF浓度,观察其与血糖、血脂、血压、肝肾功能以及糖尿病血管合并症的关系。结果:糖尿病组有血管合并症者血清VEGF高于无血管合并症者及对照组(P<0.05),而后2组差异无统计学意义;甘油三酯、低密度脂蛋白、缺血性心脏病、闭塞性动脉硬化和视网膜病变是影响血清VEGF水平的危险因素。糖尿病组血清HGF低于对照组,糖尿病微血管合并症组血清HGF低于大血管合并症组和无血管合并症组(P<0.05);空腹血糖、糖尿病神经病变、肾病和周围神经病变是影响HGF水平的危险因素。VEGF与HGF未见直线相关性。结论:VEGF与血管合并症密切相关,缺氧会代偿性诱导体内合成分泌大量VEGF,而与血糖无关;高血糖抑制HGF的合成,而与血管合并症间未见明显相关。
Objective： To study the relationship between VEGF, HGF and diabetic vascular complications. Methods： Levels of VEGF and HGF were studied in 126 type 2 diabetes and 30 controls by ELISA. The relationships between VEGF or HGF and blood glucose, lipid profile, blood pressure, liver function, renal function and diabetic vascular complications were observed. Results： VEGF was significantly higher in vascular complication group than those in non-vascular complication group and control group （P 〈 0.05）, and there was no significant difference between non-vascular complication group and control group. Tfiglyceride, LDL, ischemlc heart disease, arteriosclerosis obliterans and diabetic retinopathy were risk factors of serum VEGF level. HGF was lower in diabetes groups than that in control group, and it was lower in diabetic microvascular complication group than those in macrovascular complication group and non-vascular complication group （P〈 0.05）. Blood glucose, diabetic neuropathy, nephropathy and peripheral neuropathy were risk factors of serum HGF level. There was no relationship between VEGF and HGF. Conclusion： VEGF is positively correlated to vascular complication and it is ignored to the blood glucose level, hypoxia can increase synthesis and secretion of VEGF. Hyperglycemia inhibits the synthesis of HGF, and HGF shows no correlation with vascular complication.
出处
《天津医药》
CAS
北大核心
2006年第1期7-9,共3页
Tianjin Medical Journal
