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草酸铂联合TNF腹腔内注射治疗胃肠道肿瘤所致腹水 被引量:7

Effects of oxaliplatin combined with TNF by intraperitoneal perfusion for malignant ascites
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摘要 目的:观察草酸铂(L-OHP)联合新型重组人肿瘤坏死因子(NrhTNF)腹腔内注射治疗恶性腹水的临床疗效、不良反应、对生存质量的影响。方法:20例晚期胃肠道肿瘤所致恶性腹水患者,(L-OHP)联合NrhTNF腹腔内注射,每周1次,连续2周。结果:20例患者无CR,PR55%(11/20),SD35%(7/20)。主要不良反应为腹痛、发热、恶心,均较轻微。生活质量改善80%(16/20)。结论:(L-OHP)联合NrhTNF腹腔内注射治疗晚期胃肠道癌性腹水效果显著,不良反应轻微,可明显改善患者生存质量。 Objective:To observe the clinical effects, side effects and influence on survival quality of oxaliplatin combined with new recombinant human tumor necrosis factor (NrhTNF) by intraperitoneal perfusion for malignant ascites. Methods:Twenty patients with malignant for malignant ascites. Methods:Twenty patients with malignant ascites caused by gastrointestinal tumor were treated with oxaliplatin combined with NrhTNF by intraperitoneal perfusion once a week for two weeks. Results:In twenty patients,there were no CR,but PR 55%(11/20),SD 35%(7/20). The major side effects were abdominal pain,fever and nausea,all of them were mild. The survival quality got improved in 80%(16/20) of patients. Conelusion:Intraperitoneal perfusion of oxaliplatin combined with NrhTNF had a good effect for malignant aseites caused by gastro-intestinal tumor with mild side effects, and could significantly improve the patients' survival quality.
作者 朱青山
出处 《现代医药卫生》 2006年第6期800-801,共2页 Journal of Modern Medicine & Health
关键词 恶性腹水 草酸铂 新型重组人肿瘤坏死因子(NrhTNF) 腹腔注射 malignant ascites Oxaliplatin New recombinant human tumor necrosis factor(NrhTNF) Intraperitoneal perfusion
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