摘要
目的探讨2型糖尿病早期肾病患者血清总同型半胱氨酸(THCY)浓度的变化,并分析其影响因素和临床意义。方法应用荧光偏振免疫发光法测定血清THCY浓度。结果①2型糖尿病微量白蛋白尿组血清THCY水平明显高于正常白蛋白尿组和正常对照组(P=0.013,P=0.024),正常白蛋白尿组血清THCY水平与正常对照组相比差异无显著性(P=0.644);②经多元逐步回归分析,CCR、TG是糖尿病患者血清THCY浓度的独立影响因素,血清THCY浓度和DM病程是尿白蛋白排泄率(UAER)的独立影响因素。结论①2型糖尿病微量白蛋白尿患者血清THCY浓度升高,CCR是血清THCY浓度的独立影响因素;②高HCY血症与2型DM早期肾病的发生、发展有关。
Objective To investigate the change of serum total homocysteine in type 2 diabetics with incipient diabetic nephropathy and its clinical significance. Methods Serum tHCY levels were measured by fluorescence polarization immunoassay（FPIA） in 60 patients with type 2 diabetes and 30 healthy control subjects. The relationship between tHCY and FPG, HbA1c, FINS, Homa IR, SCr, CCr, TG, TC or UA was analysed. Results ①The serum tHCY level was higher in patients with type 2 diabetes mellitus with microalbuminuria than that in patients with normoalbuminuria and that in control subjects [ （ 11.62±4. 26 ） μmol/L vs （ 9.73 ± 2.41 ）μmol/L, P = 0. 013 ; （ 11.62±4. 26） μmol/L vs（9. 34±2. 64}μmol/L,P = 0. 024 ], while the serum tHCY level in patients with normoalbuminuria was similar to that in control subjects[ （9.73 ±2.41 ）μmol/L vs（9. 34±2. 64）μmol,P =0. 644]. ②By stepwise regression analysis, CCr and TG were independent contributors to serum tHCY level in type 2 diabetes, while serum tHCY and durations of DM were independent contributors to UAER in type 2 diabetes. Conclusions ①Patients with type 2 diabetes with microalbuminuria had an elevated tHCY level. CCr was independent contributor to serum tHCY level. ②Hyperhomocysteinemia was related to the development of incipient diabetic nephropathy.
出处
《滨州医学院学报》
2006年第1期1-3,共3页
Journal of Binzhou Medical University
关键词
同型半胱氨酸
2型糖尿病
糖尿病肾病
肌酐清除率
尿白蛋白排泄率
homocysteine, type 2 diabetes mellitus, diabetic nephropathy, creatinine clearance, urinary ＂albumin excretion rate
