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细胞间粘附分子1和C反应蛋白与2型糖尿病并发动脉粥样硬化的关系 被引量：2

Associations between Intercellular Adhesion Molecule-1 and High-Sensitivity C-Reactive Protein with Atherosclerosis in Type 2 Diabetes Mellitus Patients
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摘要 目的观察血清可溶性细胞间粘附分子1、高敏C反应蛋白与2型糖尿病并发动脉粥样硬化的关系。方法在2型糖尿病患者(伴或不伴动脉粥样硬化)和正常对照组分别用免疫散射比浊法、酶联免疫吸附法测定血清可溶性细胞间粘附分子1、高敏C反应蛋白水平,并用多普勒超声诊断仪检测颈动脉内膜中膜厚度及斑块形成情况。结果2型糖尿病患者血清可溶性细胞间粘附分子1、高敏C反应蛋白水平较正常对照组明显增高(P<0.01);2型糖尿病患者伴动脉粥样硬化组较2型糖尿病患者不伴动脉粥样硬化组血清可溶性细胞间粘附分子1水平明显增高(P<0.01),而高敏C反应蛋白水平差异无显著性。2型糖尿病患者发生动脉粥样硬化与血清可溶性细胞间粘附分子1呈正相关。结论可溶性细胞间粘附分子1对糖尿病患者动脉粥样硬化的发生有特殊的作用;高敏C反应蛋白不是2型糖尿病患者发生动脉粥样硬化的独立危险因素。 Aim To investigate the associations between soluble intercellular adhesion molecule-1 （sICAM-1 ） and highsensitivity C-reactive protein （hs-CRP） with athewsclerosis in type 2 diabetes mellitus patients （T2DM）. Methods The levels of sICAM-1 and hs-CRP in T2DM with or without atherosclerosis and normal comtrols was deter, sICAM-1 was measaued by enzyme-linked immunosorbent assay, hs-CRP was measured by immuoturbidimetric method. The carotid intima-media thickmess （IMT） and carotid plaques were measured by ultrasound. Results The levels of sICAM-1 and hs-CRP in T2DM with or without atherosclerosis were higher than those in normal comtrols （ P 〈 0.01 ）, and the levels of sICAM-1 in T2DM with atherosclerosis were higher than that in T2DM without atherosclerosis （ P 〈 0.01 ）. Conclusions sICAM-1 is a special risk factor for atherosclerosis in T2DM, but hs-CRP is not.
作者 卢曙芳 沈建国
机构地区 绍兴文理学院医学院附属医院内科 浙江大学医学院附属第一医院内分泌科
出处 《中国动脉硬化杂志》 CAS CSCD 2005年第6期771-774,共4页 Chinese Journal of Arteriosclerosis
关键词 内科学 细胞问粘附分子1与动脉粥样硬化的关系 酶联免疫吸附法 可溶性细胞间粘附分子1 2型糖尿病 高敏C反应蛋白 Soluble Intercellular Adhesion Molecule-1 Type 2 Diabetes High-Sensitivity C-Reactive Protein Atherosclerosis Intima-Media Thickness
分类号 R5 [医药卫生—内科学]
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参考文献9

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共引文献64

同被引文献14

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中国动脉硬化杂志
2005年 第6期

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