高原地区健康老年人同型半胱氨酸水平与血管内皮细胞功能的相关性被引量：15

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摘要血管内皮细胞（VEC）功能损伤是冠心病发病机制之一。同型半胱氨酸（Hcy）是冠状动脉疾病、脑血管疾病、外周血管闭塞性疾病的独立危险因素。我们在临床观察中发现，长期居住在高原缺氧环境下的健康人群，特别是中老年人是心、脑血管疾病和外周血管闭塞性疾病发病的高危人群。我们对高原地区健康老年人血液中Hcy水平与代表VEC功能指标的可溶性血管内皮细胞黏附分子-1（sVCAM-1）、一氧化氮（NO）含量和一氧化氮合酶（NOS）活性进行检测分析，旨在为该地区健康老年人心脑血管疾病的发生、发展提供研究依据。

作者阿祥仁王立萍张鑫生

机构地区青海省人民医院检验科青海省人民医院干部保健科

出处《中华老年医学杂志》 CAS CSCD 北大核心 2006年第2期123-124,共2页 Chinese Journal of Geriatrics

关键词血管内皮细胞功能健康老年人同型半胱氨酸高原地区外周血管闭塞性疾病心脑血管疾病内皮细胞黏附分子一氧化氮合酶病发病机制冠状动脉疾病

分类号 R446.6 [医药卫生—诊断学]

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