摘要
瞄准：为了评估本地肿瘤的用途，治疗为恶意的妨碍的胆汁的疾病把胆汁的排水(PTBD ) 与经皮的 transhepatic 相结合。方法：有恶意的胆汁的阻塞的 233 个病人的一个总数被金属性的 stents 或塑料试管的放置与 PTBD 在我们的医院里对待。在 PTBD 以后， 49 个病人接受了 brachytherapy 或额外放射的治疗或动脉的注入化疗。病人被跟随在上面与临床、 X 光线照相术的评估。幸存和斯滕特氏印模膏明显率被 Kaplan-Meier 幸存分析计算。结果： 22 个病人经历了化疗(肝的癌的 11 个盒子，胰腺的癌的 7 个盒子，变形淋巴结病的 4 个盒子)，并且 14 个病人收到了放射疗法( cholangiocarcinoma 的 10 个盒子，胰腺的癌的 4 个盒子)，并且 13 个病人接受了 brachytherapy ( cholangiocarcinoma 的 7 个盒子，胰腺的癌的 3 个盒子，变形淋巴结病的 4 个盒子)。在 1， 3， 6，和 12 个月的本地肿瘤治疗组的幸存率分别地是 97.96% ， 95.92% ， 89.80% ，和 32.59% ，比的长非治疗组。在 1， 3， 6，和 12 个月的明显率分别地是 97.96% ， 93.86% ， 80.93% ，和 56.52% 。明显率的差别不在治疗组之间是重要的，非，治疗组织。结论：我们的结果建议那本地肿瘤治疗能与恶意的胆汁的阻塞延长病人的生存时间，并且可以改进斯滕特氏印模膏明显。
AIM： To evaluate the utility of local tumor therapy combined with percutaneous transhepatic bilian/drainage （PTBD） for malignant obstructive bilian/disease. METHODS： A total of 233 patients with malignant billan/obstruction were treated in our hospital with PTBD by placement of metallic stents and/or plastic tubes. After PTBD, 49 patients accepted brachytherapy or extraradiation therapy or arterial infusion chemotherapy. The patients were followed up with clinical and radiographic evaluation. The survival and stent patency rate were calculated by Kaplan-Meier survival analysis. RESULTS： Twenty-two patients underwent chemotherapy （11 cases of hepatic carcinoma, 7 cases of pancreatic carcinoma, 4 cases of metastatic lymphadenopathy）, and 14 patients received radiotherapy （10 cases of cholangiocardnoma, 4 cases of pancreatic carcinoma）, and 13 patients accepted brachytherapy （7 cases of cholangiocarcinoma, 3 cases of pancreatic carcinoma, 4 cases of metastatic lymphadenopathy）. The survival rate of the local tumor treatment group at 1, 3, 6, and 12 months was 97.96%, 95.92%, 89.80%, and 32.59% respectively, longer than that of the non treatment group. The patency rate at 1, 3, 6, and 12 months was 97.96%, 93.86%, 80.93%, and 56.52% respectively. The difference of patency rate was not significant between treatment group and non treatment group. CONCLUSION： Our results suggest that local tumor therapy could prolong the survival time of patients with malignant biliary obstruction, and may improve stent patency.
基金
Supported by the Natural Science Foundation of Beijing, No.7982035
