摘要
目的探讨门冬氨酸-鸟氨酸治疗慢性乙型肝炎的疗效和安全性。方法30例慢性乙型肝炎住院病人先接受瑞甘冻干粉针剂10．0g（2．5g/支）溶入5％葡萄糖液250mL中，静脉滴注，1次/d，连续20d；后改用瑞甘颗粒剂，3次/d，每次2袋（1．0g／袋），连续服用8wk，总疗程为76d。观察治疗前后肝功能和乙型肝炎病毒标志物指标变化。结果治疗结束时显示，门冬氨酸-鸟氨酸对慢性乙型肝炎病人的临床表现和肝功能具有良好的改善作用，总有效率达76．6％。尤对ALT，AST，γ-GT及TB恢复效果比较明显，统计学有显著性差异。P值分别为〈0．01，〈0．01，〈0．01和〈0．05。结论门冬氨酸-鸟氨酸作为一种新的护肝药物，对慢性乙型肝炎病人的肝功能改善疗效明显，值得在综合治疗中加以采用。
Aim To explore the efficacy and safety of L-ornithine-L-aspartate in the management of chronic Hepatitis B. Method 30 patients with Chronic Hepatitis B hospitalized were received fn＇st of 20 days therapy with L-ornithine-L-aspartate injection, which dose of 10.0g be dissolve in 5% glucose 250ml by intravenous infusion once daily. The patients take orally with L-ornithine-L-aspartate granules on 8 weeks by three times （2.0g every time） daily follow. The liver function and hepatitis B virus mark were observed in all patients at the onset and end of treatment. Results The end of treatment shows that L-ornithine-L-aspartate improved clinical manifestations and liver function of patients with chronic Hepatitis B. The curative effect of total effective was 76.6%. The serum ALT, AST、γ-GT, bilirubin level of patients marked effective. The statistics were significant difference, the P〈0.01, 〈0.01, 〈0.01, and 〈0.05, respectively. Conclusion The L-orhithine-L-aspartate can effectively improve liver function of patients with Chronic Hepatitis B, and should be enrolled into the comprehensive therapy of chronic hepatitis.
出处
《世界感染杂志》
2006年第1期64-66,共3页
World Journal of Infection
