摘要
背景与目的:宫颈癌是妇女常见的恶性肿瘤之一。目前大量的研究认为HPV是宫颈癌的主要致病因素,几乎所有C IN都伴有HPV亚型。本研究旨在评价HPV-DNA检测对宫颈病变的诊断价值。方法:对320例HPV-DNA检测患者在宫颈病变检查方面的资料进行分析。结果:①HPV-DNA高危型阳性患者无明显临床症状,妇科检查以宫颈糜烂为主要表现,②C IN发病率在HPV-DNA高危型阳性组30%,阴性组11%(P<0.01),③HPV-DNA高危型阳性的C IN患者中17%是高度病变(C IN-Ⅱ及以上),阴性组仅2%(P<0.05)④随细胞学检查的级别增高,HPV-DNA高危型阳性率增加(P<0.05),HPV感染发生率增加(P<0.01),C IN发生率增加(P<0.05)。结论:HP-DNA高危型患者C IN发病率较高,C IN高度病变比例较高,HPV-DNA检测在宫颈病变的检查中有重要意义;如与宫颈细胞学检查和阴道镜检查结合可提高宫颈病变的检出率。
Background and Purpose： Cervical cancer is one of most common types of malignant tumor in women, Human papillomaviruses （HPV） are considered as the prime etiologic suspects, and analysis of almost all CIN lesions shows the presence of a subtype of HPV. The study aims to evaluate the significance of HPV-DNA testing in cervical displasia diagnosis. Methods： to analyse medical records of 320 patients with HPV-DNA tests. Results： ①Most of the patients with positive high risk types of HPV-DNA have cervical inflammation. ②CIN incidence is 30% in positive high risk types of HPV-DNA and 11% in negative （P 〈0.01）, ③ 17% of CIN patients with positive high risk types of HPV-DNA are highgrade （≥CIN-Ⅱ）, and with negative only 2% （P 〈0.05）, ④ With increase of the grade of cervical cytology, the incidence increases in the patients with positive high risk types of HPV-DNA（ P 〉 0.05）, HPV infection（P 〉 0.01 ） and CIN（P 〉0.05）. Conclusions： The incidence of CIN and especially high-grade CIN are higher in patients with positive high risk types of HPV-DNA than negative. HPV-DNA testing has significance in the diagnosis of cervical displasia; HPV-DNA testing combined with pap smear and eolposcopy can increase the diagnosis of cervical diaplasia.
出处
《中国癌症杂志》
CAS
CSCD
2006年第3期217-219,共3页
China Oncology
