摘要
目的：研究菝葜醋酸乙酯提取物对大鼠和小鼠急性、慢性炎症的抗炎作用。方法：采用蛋清致足肿胀、甲醛致足肿胀、二甲苯致耳肿胀和醋酸致腹膜炎模型，对菝葜醋酸乙酯提取物对急性（早期）、慢性（晚期）炎症的抗炎作用进行研究，处理为正常对照组：生理盐水，10mL·kg^-1；乙酰水杨酸阳性对照组（200mg·kg^-1）；菝葜提取物剂量为生药50，100g·kg^-1剂量组，均灌胃给药。结果：在生药50—100g·kg^-1剂量范围内，提取物能显著降低蛋清诱导的大鼠足跖肿胀度、甲醛诱导的小鼠足肿胀程度、小鼠腹腔毛细血管通透性增高和二甲苯诱导的耳廓肿胀，同时对炎症晚期也有一定的抑制作用。结论：菝葜醋酸乙酯提取物对急性、早期炎症具有明显的抗炎作用，对炎症晚期也有一定的抑制作用。
Objective： To study the anti-inflammations of the ethyl acetate extract of S. china on acute and chronic inflammations. Method： The rat paw edema induced by egg-albumin, the ear edema and the foot edema of mice induced by xylene and formaldehyde, the increased vascular permeability of capillary induced by intraperitoneal injection of 0.7% acetic acid in mice were used to study on the acute, early inflammations and chronic inflammation for the ethyl acetate extract of S. china. Result： The extract （50-100 g·kg^-1） could significantly decrease the rat paw edema,and inhibit the ear edema, the increased vascular permeability and the foot edema of mice.Conclusion： The ethyl acetate extract of S. china possesses remarkable anti-inflammatory effects on acute inflammation, and also displays anti-inflammatory effects on the chronic inflammation at a certain extent.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2006年第3期239-243,共5页
China Journal of Chinese Materia Medica
关键词
菝葜
醋酸乙酯提取物
抗炎作用
Smilax china
ethyl acetate extract
anti-inflammations
