摘要
研究了缬氨酸在二苯甲酰L-酒石酸乙醇溶液中的非均相消旋新工艺,进行了消旋动力学研究,并与碱液消旋进行了比较。随着二苯甲酰L-酒石酸用量和消旋反应时间的增加,缬氨酸的消旋率逐渐增加。L-缬氨酸的非均相消旋反应速率常数与反应温度的关系为:k=0.015 5-13R 2T00,其活化能Ea大大低于碱液消旋中的Ea值,消旋反应条件温和,容易分离,适合工业化生产。
A new heterogeneity racemization technology of valine in an ethanol solution of dibenzoyl-L-tartaric acid was described. Racemization kinetics of this process was studied. Racemization ratio of valine could be gradually increased when the amount of dibenzoyl-L-tartaric acid and the time of racemization were increased For L-Valine, the relationship between the rate constant of racemization and its reaction temperature was proposed, i. e. ：k =0. 015 5e^-13200/RT, Ea of the heterogeneity racemization is much less than Ea of the racemization in the basic solution. The heterogeneity racemization technology would be suitable for large-scale industrial manufacture.
出处
《应用化学》
CAS
CSCD
北大核心
2006年第3期340-342,共3页
Chinese Journal of Applied Chemistry
基金
湖北省教育厅重点科研计划项目(B200513002)
