摘要
目的探讨血尿酸(SUA)水平与2型糖尿病(T2DM)及T2DM并发冠心病的关系和SUA的影响因素。方法80例T2DM患者(DM组)、92例T2DM并发冠心病患者(DC组)及119例健康查体者(NC组),均检测SUA。结果(1)SUA水平NC组为280±81 mmol/L、DM组257±76 mmol/L,DC组302±72 mmol/L;DM组的SUA水平较NC组(P=0.037)、DC组(P=0.000)明显降低,DC组较NC组SUA水平有升高趋势(P=0.050);(2)男性SUA水平高于女性(t=3.330,P=0.001);(3)男性腰臀比(R=0.354)为SUA的独立影响因素;女性年龄(R=0.623)和体质指数(R=0.286)为SUA的独立影响因素;(4)高尿酸血症是T2DM并发冠心病的独立危险因素,并与吸烟和高血压有协同作用。结论DM组患者较NC组SUA水平下降,而相同病程的T2DM并发冠心病患者SUA反而升高;男性SUA高于女性,且两性SUA的影响因素不同。
Objective To investigate the relationship of serum uric acid（SUA） with type 2 diabetes mellitus and diabetic macrovascular complications and to study the influential factors of SUA. Methods Recruited were eighty type 2 diabetic patients（group B）, ninety-two type 2 diabetic patients with coronary artery disease（group C） and one hundred and twelve healthy controls（group A） whose qualitative urine protein assay were negative. Serum concentrations of uric acid and other biochemical materials were assayed at a fasting state. The sensitivity of insulin was also evaluated. Results （1） The SUA levels in group A, B and C were（280±81）（257±76） and （302±72） mmol/L respectively; SUA in group B was lower than that in group A（P=0. 037） or group C（P=0. 000） and SUA in group C tended to be higher than that in group A（P=0. 050）. （2） SUA level significantly increased in man than in woman（P=0. 001）. （3） The independent influential factors of SUA were WHR（R=0. 354） in man, and BMI（R=0. 286） and age（R=0. 623） in woman. （4） After adjusting the age, sex, distribution of body fat and serum lipid level, the logistic regression analysis of group B and C showed that hyperuricemia was the independent risk factor for diabetic macrovascular complications, and this was especially obvious in smoker or hypertensive patient. Conclusions SUA in type 2 diabetic patients is lower than that in both healthy controls and type 2 diabetic patients with coronary disease. The level and contributing factors of SUA are different between men and women.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2006年第1期20-22,共3页
Chinese Journal of Diabetes
关键词
尿酸
糖尿病
2型
冠状动脉性心脏病
Uric acid
Diabetes mellltus, type 2
Coronary heart disease
