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作为免疫相关性疾病靶点的DcR3的研究进展 被引量：2

Advance on DcR3 as a target of immune associated disease
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摘要 诱骗受体3(decoy receptor 3,DeR3)是肿瘤坏死因子受体超家族的新成员。它通过拮抗Fas／FasL系统及LIGHT／ LTβR、LIGHT／HVEM/TR2系统的作用,在肿瘤及免疫性疾病中发挥重要作用。DcR3的基因位于20q13．3,在人肿瘤细胞中会发生基因扩增和重排;在多种肿瘤、自身免疫疾病中高表达;作用机制有LIGHT和配体FasL途径等;促肿瘤发生;可下调宿主免疫功能,能降低T细胞对同种抗原应答,有重大开发潜能。
作者 李文珠 庄国洪 颜江华 陶惠然
机构地区 厦门大学生命科学院 厦门大学医学院
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 2006年第1期67-69,76,共4页 Chinese Journal of Cancer Biotherapy
基金 厦门大学科研启动基金资助(NO.Z03103)
关键词 DCR3 肿瘤 自身免疫病 移植免疫
分类号 R730.231 [医药卫生—肿瘤]
  • 相关文献

参考文献19

  • 1Li H,Zhang L,Lou H,et al.Overexpression of decoy receptor 3in precancerous lesions and adenocarcinoma of the esophagus[J].Am J Clin Pathol,2005,124(2):282-287.
  • 2Pitti RM,Marsters SA,Lawrence DA,et al.Genomic amplification of a decoy receptor for Fas ligand in lung and col() cancer[J].Nature,1998,396(6712):699-703.
  • 3Bai C,Connolly B,Metzker ML,et al.Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster[J].Proc Natl Acad Sci USA,2000,97(3):1230-1235.
  • 4Gill RM,Hunt JS.Soluble receptor (DcR3) and cellular inhibitor of apoptosis-2(cIAP-2) protect human cytotrophoblast cells against LIGHT-mediated apoptosis[J].Am J Pathol,2004,165 (1):309-317.
  • 5Chang YH,Hsieh SL,Chao Y,et al.Proinflammatory effects of LIGHT through HVEM and LTβR interactions in cultured human umbilical vein endothelial cells[J].J Biomed Sci,2005,12(2):363-375.
  • 6Wortinger MA,Foley JW,Larocque P,et al.Fas ligand-induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue[J].Immunology,2003,110(2):225-233.
  • 7Yang CR,Hsieh SL,Teng CM,et al.Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1 A,a cytokine belonging to tumor necrosis factor superfamily and exhibiting angiostatic action[J].Cancer Res,2004,64(3):1122-1129.
  • 8Yang CR,Wang JH,Hsieh SL,et al.Decoy receptor3 (DcR3)induces osteoclast formation from monocyte/macrophage lineage precursor cells[J].Cell Death Differ,2004,11 (27):97-107.
  • 9Hsu MJ,Wan-Wan L,Wei-Chia T,et al.Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3[J].Exp Cell Res,2004,292(2):241-251.
  • 10Arakawa Y,Tachibana O,Hasegawa M,et al.Frequent gene amplification and overexpression of decoy receptor 3 in glioblastoma[J].Acta Neuropathol (Berl),2005,109(3):294-298.

二级参考文献9

  • 1Pitti RM, Marsters SA, Lawrence DA, et al. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature,1998,396:699-703.
  • 2Bai C, Connolly B, Metzker ML, et al. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. Proc Natl Acad Sci USA, 2000,97:1230-1235.
  • 3Roth W, Isenmann S, Nakamura M, et al. Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligandinduced apoptosis and chemotaxis. Cancer Research, 2001,61:2759-2765.
  • 4Yu KY, Kwon B, Ni J, et al. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHTmediated apoptosis. J Biol Chem, 1999,274:13733-13736.
  • 5Ohshima K, Haraoka S, Sugihara M, et al. Amplification and expression of a decoy receptor for fas ligand ( DcR3 ) in virus ( EBV or HTLV-Ⅰ) associated lymphomas. Cancer Lett , 2000,160:89-97.
  • 6Otsuki T, Tomokuni A, Sakaguchi H, et al. Over-expression of the decoy receptor 3 ( DcR3 ) gene in peripheral blood mononuclear cells( PBMC ) derived from silicosis patients. Clin Exp Immunol, 2000,119:323-327.
  • 7Gelmini S, Orlando C, Sestini R, et al. Quantitative polymerase chain reaction-based homogeneous assay with fluorogenic probes to measure c-erbB-2 oncogene amplification. Clinical Chemistry, 1997,43:752-758.
  • 8Sinicrope FA, Ruan SB, Cleary KR, et al. Bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res,1995,55:237-241.
  • 9Ibrahim SM, Ringel J, Schmidt C, et al. Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death.Pancreas, 2001,23:72-79.

共引文献19

同被引文献15

  • 1王鲁平,陈健,宁浩勇,刘光,丁华野,虞积耀,Charles B,Underhill,张鲁榕.TR6在人乳腺癌中的功能、表达和意义[J].诊断病理学杂志,2005,12(2):133-136. 被引量：12
  • 2单国平,徐美荣,吕强声,池鸣鸣.DcR3和CD105标记的MVD在乳腺癌中的表达及其意义[J].中国现代医学杂志,2007,17(5):528-531. 被引量：6
  • 3陈罡,罗殿中.肝细胞癌中肿瘤坏死因子受体6的表达[J].中华肝脏病杂志,2007,15(4):302-303. 被引量：4
  • 4单国平,徐美荣,吕强声,池鸣鸣.诱导受体3在乳腺癌中的表达及其临床意义[J].中国肿瘤临床与康复,2007,14(2):97-100. 被引量：6
  • 5Pitti RM,Marsters SA,Lawrence DA, et al. Genomic amplifi- cation of a decoy receptor for Fas ligand in lung and colon canc- er[J].Nature, 1998,396(6712):699-703.
  • 6Wu Y, Han B, Sheng H, et al. Clinical significance of detec-ring elevated serum DcR3/TR6/M68 in malignant tumor pa- tients[J], fnt J Cancer, 2003,105 (5) : 724-732.
  • 7Chen G, Luo D. Expression of decoy receptor 3 in liver tissue mieroarrays[J]. Natl Med J India, 2008, 21 (6) :275-278.
  • 8Chen G, Luo D. Over-expression of decoy receptor 3 in gastric precancerous lesions and carcinoma[J]. Ups J Med Sci, 2008, 113(3) :297-304.
  • 9Ashkenazi A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily [J ]. Nat Rev Cancer, 2002,2(6) : 420-403.
  • 10Lakhani SA, Masud A, Kuida K, et al. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis[J].Science, 2006,311 (5762) :847-851.

引证文献2

二级引证文献7

中国肿瘤生物治疗杂志
2006年 第1期

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