摘要
目的探讨甾体类和非甾体类消炎药对准分子激光原位角膜磨镶术(LASIK)后泪膜及角膜知觉的影响。方法将54例(100只眼)接受LASIK治疗的近视患者随机分为2组,术后分别给予0．3％妥布霉素+0． 1％地塞米松滴眼液及0．3％妥布霉素+0．1％普拉洛芬滴眼液。术后1、2、4周对随访患者进行Schirmer试验、泪膜破裂时间(BUT)、中央角膜知觉检查和主观干眼症状调查。结果术后各时间段两组患者的Schirmer值、主观干眼症状评分差异无显著性意义。术后1、2周两组BUT值和中央角膜知觉的差异有统计学意义,而术后4周差异无显著性。结论 LASIK术后早期,应用NSAIDs的患者泪膜更不稳定,角膜知觉的恢复较甾体类消炎药组缓慢。 NSAIDs对泪膜稳定性及中央角膜知觉的影响大于甾体类消炎药。
Objective To evaluate the effects of NSAIDs and steroid on tear film and corneal sensitivity after laser in situ keratomileusis （LASIK）. Methods 100 eyes of 54 patients with myopia underwent LASIK were divided into 2 groups randomly. The first group was given 0.3% tobramycin and 0.1% dexamethason after surgery. The second group was given 0.3% tobramycin and 0.1% pranoprofen after surgery. Both groups were examined Schirmer test, breakup time （ BUT）, corneal sensitivity before and 1 week, 2 weeks and 4 weeks after LASIK. Dry-eye symptoms were assessed using the McMonnies Dry Eye Symptom Survey. Results No significant difference in Schirmer test and subjective score for dry eye Symptom between the two groups was found at any time spot after surgery. BUT and corneal sensitivity differed significantly between the two groups 7 days and 14 days postoperatively. And the differences were not significant after 4 weeks. Conclusion At the early stage of postoperation, NSAIDs has more effect on the recovery of tear film stability and corneal sensitivity than steroid. The tear film stability of NSAIDs group was more unstable, and the recovery of corneal sensitivity was slower.
出处
《临床眼科杂志》
2006年第1期12-14,共3页
Journal of Clinical Ophthalmology
