摘要
目的:评价国产苯溴马隆治疗2型糖尿病合并高尿酸血症的疗效与安全性。方法:2型糖尿病合并高尿酸血症96例,在控制血糖、血压后,分成2组;试验组64例,在进行低嘌呤饮食的基础上,给予国产苯溴马隆50 mg·d^(-1),qd;对照组32例,仅给予低嘌呤饮食。疗程4周。测定第2,4周血尿酸含量和24 h尿尿酸排泄量。结果:治疗后第2,4周试验组血尿酸值均明显下降(P＜0．05),24 h尿尿酸排泄量均明显升高(P＜0．05);对照组变化无统计学意义。试验组无明显不良反应发生。结论:国产苯溴马隆对2型糖尿病合并高尿酸血症降尿酸安全有效。
Objective：To evaluate the efficacy and safety of domestic Benzbromarone for the treatment of type 2 diabetes complicated with hyperurieaemia. Methods： After controlling blood glucose and blood pressure,96 patients with type 2 diabetes and hyperuricaemia were divided into two groups： treatment group was administrated with domestic Benzbromarone 50 mg once daily for 4 weeks,while control group was given only diet control. Results：Serum uric acid decreased and uric acid excreted within 24 hours increased significantly （ P 〈 0.05 ） after 2 weeks treatment in treatment group, while control group had no significaut change （ P 〉 0. 05）. No obvious adverse reactions were reported. Conclusion ： The domestic Benzbromarone is an effective and safe uricosuric medicine and is convenient to use in treating type 2 diabetes complicated with hyperuricaemia.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2006年第4期301-303,共3页
Chinese Journal of New Drugs
