摘要
目的探讨近年来我国肝硬化病因的特点及其变化。方法回顾性分析我院1994年1月～2004年12月824例肝硬化出院患者的病因。结果乙型肝炎后肝硬化504例（61．17％），酒精性肝硬化73例（8．86％），乙型病毒性肝炎合并酒精性肝硬化152例（18．45％），自身免疫性肝硬化19例（2．31％），非酒精性脂肪性肝硬化者31例（3．76％）。按时期分为前6年和后5年分别分析。显示乙型肝炎肝硬化由66．67％下降到57．65％，随时间呈下降趋势。酒精性肝硬化由2．49％增加到12．92％，非酒精性脂肪性肝硬化由1．56％增加到5．19％，自身免疫性肝硬化由1．25％增加到2．98％，均随时间呈增加趋势。本组患者中139例（16．87％）合并原发性肝癌，其中128例为乙肝后肝硬化，9例酒精性肝硬化，1例非酒精性脂肪性肝硬化。结论虽然乙型病毒性肝炎仍然为我国肝硬化的主要病因，但是酒精性肝硬化和非酒精性脂肪性肝硬化随时间呈上升趋势，且非酒精性脂肪性肝硬化的预后与乙肝后肝硬化比较差异无统计学意义，应该引起足够重视。
Objective To analyze the causes of liver cirrhosis and their changes in recent years in the Second Affiliated Clinical College of Chongqing University of Medical Sciences. Methods Eight hundreds and twenty-four inpatients with liver cirrhosis（Jan. 1994 to Dec. 2004）were investigated retrospectively. Results Five hundreds four（61.17% ）cases were caused by the infection of hepatitis B virus. Thirty（3.76 % ）cases were caused by NAFLD and 73（8.86 % ）cases were caused by alcohol . Two factors（hepatitis B virus and alcohol）existed in 152（18.45 %0 ） patients . The patients were divided into two groups of before-Jan. 2000 and after- Jan. 2000,and the above etiological factors were further analyzed . It was found that the incidence of alcoholic cirrhosis increased from 2.49% to 12.92% ,also the incidence of cirrhosis caused by NAFLD increased from 1.56% to 5.19% . But the incidence of cirrhosis caused by HBV was decreased from 66.67 % to 57.65 % . Conclusion It is suggested that HBV is still the major cause of liver cirrhosis in China. Cirrhosis caused by alcohol and NAFLD reveals a tendency of increase, to which much attention should be paid.
出处
《重庆医学》
CAS
CSCD
2006年第5期438-439,441,共3页
Chongqing medicine
关键词
肝硬化
病因
病毒性肝炎
酒精
非酒精性脂肪性肝病
cirrhosis
etiology, viral hepat itis
alcohol
NAFLD（nonalcoholic fatty liver disease）
