摘要
老年性痴呆(Alzheimer's disease,AD)是一种与年龄相关的中枢神经系统退行性病变。由于至今其病因不明、发病机制复杂,制约了该病动物模型的制作研究工作。本文对各类AD动物模型的研究进展及其优劣进行了评价,认为Tg2576转基因小鼠已成为较合适的防治AD新药研究的动物模型。
AD is a kind of age-related degeneration disease in nervous system .The research of animal models ofAlzheimer＇s disease is restrictive because it＇s cause isn＇t clear and etiopathogenesis The authors reviewed and evaluated various kind of AD animal models and concluded that the Tg2576 mice had been a suitable animal model for testing of novel anti-AD drugs.
出处
《实验动物与比较医学》
CAS
2006年第1期50-53,共4页
Laboratory Animal and Comparative Medicine
基金
黑龙江省自然科学基金资助项目(D00-28)
关键词
老年性痴呆
动物模型
转基因
Alzheimer＇s disease
Animal models
Transgenic animal
