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神经元特异烯醇化酶和S100蛋白在巨结肠及其类缘病中的表达 被引量:3

Expression of Neuron Specific Enolase and Soluble-Protein 100 in Hirschsprung′s Disease and Its Allied Disease
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摘要 目的探讨神经元特异烯醇化酶(NSE)和S100蛋白(S100)在巨结肠及其类缘病的表达和临床意义。方法对120例拟诊为先天性巨结肠的病变肠段行HE染色,结合光镜下肠壁神经节细胞的形态特征,并对29例应用免疫组织化学技术行NSE、S100蛋白染色,比较其染色结果和分布特点。结果巨结肠类缘病标本的神经丛及神经节细胞数与正常组比较差异有显著性(P<0.01)。结论NSE、S100可作为巨结肠与其类缘病鉴别诊断的标记物,能提高临床巨结肠类缘病的确诊率。 Objective To siscuss the expression and its significance of neuron specific enolase(NSE) and soluble-protein 100 (S100) in Hirsehsprung's disase(HD) and its allied disease. Methods Clinicopathologic data were reviewed from 120 cases of suspected HI) patients. According to the morphological characteristic of the nerve stanza cell stained with HE under the microscope. NSE and S100 immunohistochenfical staining was performed in 29 cases. Then we compared the effect of the staining with analyzed the dis. tribution. Results The number of the nerve plexus and ganglion cell of allied HD was significantly higher than that in normal control group(P〈0.01). Conclusions NSE and S100 iramunohistochemieal method can be used for the diagnosis of HD and its allied disease It will be greatly helpful in making a definite diagnosis of allied HD.
作者 王红 曾甜
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2006年第5期313-315,共3页 Journal of Applied Clinical Pediatrics
基金 广西壮族自治区卫生厅科研基金项目资助(Z20010041)
关键词 巨结肠及其类缘病 神经元特异烯醇化酶 S100蛋白 Hirschsprung's disease and its allied disease neuron-specific-enolase solube-protein 100
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