摘要
目的观察天麻提取物对家兔体外、大鼠半离体和小鼠体内血小板聚集的影响。方法用比浊法测定血小板的聚集率。结果在体外、半离体和体内实验中,天麻提取物G2能抑制由二磷酸腺苷(ADP)诱导的血小板聚集;在体外实验中,天麻提取物G2还能抑制由血小板活化因子(PAF)诱导的血小板聚集。结论天麻提取物G2具有显著的抗血小板聚集作用。
Objective To study the antiaggregation effects of fractions from Gastrodia Rhizome in vitro or in vivo. Methods The method of light transmission was used to assay the antiaggregation effects of fractions from Gastrodia Rhizome. Results We found the fraction G2 from Gastrodia Rhizome showed the moet potent inhibition of platelet aggregation. Fraction G2 possessed significant anti-platelet aggregation induced by ADP in vitro or in vivo. Fraction G~ also showed marked protection against mouse sudden death challenged by injeetiion of ADP （300mg/kg） in a dose-dependent manner. Condusion Fraction G2 had the function of inhibiting platelet aggregation.
出处
《中国微循环》
北大核心
2006年第1期33-35,共3页
Journal of Chinese Microcirculation
基金
云南省自然科学基金(2002c0057m)
关键词
天麻提取物
血小板聚集
Fractions from Gastrodia Rhizome
Platelet aggregation
