摘要
目的评估表观扩散系数(ADC)鉴别星形细胞瘤不同肿瘤组织及与细胞密度、病理分级的相关性。资料与方法采用Siemens1.5T超导型磁共振系统,对48例星形细胞瘤术前行常规MRI及扩散加权成像(DWI),其中Ⅰ、Ⅱ级23例,Ⅲ、Ⅳ级25例。分别计算不同肿瘤组织的ADC值。病理标本行HE染色,采用Image J1.33j分析每一标本的肿瘤细胞密度。用SPSS11.0对资料进行处理。结果星形细胞瘤不同肿瘤组织间及与正常脑实质的ADC值差异具有统计学意义(P<0.001);非强化的肿瘤实质与瘤周水肿区ADC值差异无统计学意义(P>0.05)。星形细胞瘤病理分级与强化肿瘤实质ADC值呈负相关,rs=-0.641(P<0.001);强化肿瘤实质的ADC值与肿瘤细胞密度呈负相关,r=-0.643(P<0.001)。结论星形细胞瘤ADC值能鉴别不同肿瘤组织,有助于评价肿瘤细胞密度及病理分级。
Objective To evaluate the usefulness of ADC in differentiating various tumor tissues of cerebral astrocytomas and its relationship with cellularity and grading of astrocytomas. Materials and Methods Using a Siemens 1.5 T Super conduct MR unit, 48 patients of astrocytoma （grade Ⅰ～Ⅱ and grade Ⅲ～Ⅳ, 23 and 25 respectively） were examined with Conventional MRI and DWI, ADC values were calculated both in the different tumor tissues and in the normal brain tissues, specimens were stained with HE. Cellularity of astrocytoma was analyzed with Image J 1.33 software postoperatively. Results Significant differences of ADC values were found in different tumor tissues of astrocytomas compared with normal brain tissue （ P 〈 0.001 ）. There was not statistical difference of ADC value between in non-enhancing solid tumor and peritumoral edema （ P 〉 0.05）. Negative correlation was existed between ADC values in enhancing solldtumor and grading of astrocytomas （ rs = - 0.641, P 〈 0.001） ; negative correlation was also existed between ADC values in enhancing solid tumor and tumor cellularity （ r = - 0. 643, P 〈 0. 001 ）. Conchlsion The ADC values can be used to differentiate tumor tissues and evaluate the tumor cellularity and grading of astrocytomas.
出处
《临床放射学杂志》
CSCD
北大核心
2006年第3期201-205,共5页
Journal of Clinical Radiology
基金
国家自然科学基金资助项目(基金编号30370433)分课题
关键词
星形细胞瘤
扩散加权成像
细胞密度
表观扩散系数
Astrocytoma Diffusion weighted imaging Cellularity Apparent diffusion coefficient
