摘要
目的:比较雷贝拉唑三联疗法与兰索拉唑三联疗法治疗幽门螺杆菌阳性消化性溃疡的疗效。方法:将幽门螺杆菌阳性的消化性溃疡83例分为两组:治疗组(雷贝拉唑三联疗法组)41例,以雷贝拉唑10mg,阿莫西林1000mg及甲硝唑400mg每日2次口服,治疗1周后单独服用雷贝拉唑10mg,连服7d;对照组(兰索拉唑三联疗法组)42例:以兰索拉唑30mg,阿莫西林1000mg及甲硝唑400mg,每日2次口服,治疗1周后单独服用兰索拉唑30mg,连服7d。治疗期间每周门诊随诊,记录临床症状改善情况,用药结束1个月后复查胃镜并检测幽门螺杆菌结果。结果:治疗组和对照组1d的临床症状缓解率分别为80%、60%,差异有统计学意义(P<0.05);1周后症状缓解率均为98%。治疗组和对照组的溃疡愈合率分别为93%和76%,差异有统计学意义(P<0.05);治疗组和对照组的总有效率分别为98%和96%,差异无统计学意义(P>0.05)。治疗组和对照组的幽门螺杆菌根除率分别85%和81%,差异无统计学意义(P>0.05)。结论:两组方案均能有效治疗消化性溃疡和缓解临床症状,并能有效地根除幽门螺杆菌。但雷贝拉唑三联疗法在改善临床症状和促进溃疡愈合方面优于兰索拉唑三联疗法。
Objective： To compare the efficacy of mrabeprazole-based and lansoprazole-based triple therapy in the treatment of Helieobacter pylori （H pylori） -positive peptic ulcer. Methods： Eighty-three patients with H pylori positive peptic ulcers were randomized into two groups： the 1st group treated with rabeprazole 10 mg bid （rabeprazole-group n= 41 ） and the 2nd group treated with lansoprazole 20 rag bid （lansoprazole-group n=42） for 1 week, all patients were given amoxicillin lg bid and metronidazole 400mg for one week after. Clinical symptoms were observed and recorded weekly. One month after treatment, the eradication rate of H priori and the healing rate of peptic ulcer were evaluated according to result of repeated endoscope. Results： The relief rate for clinical symptoms in rabeprazole-group and lansoprazole- group was 80% and 60% respectively at one day finishing regimen （P 〈 0.05）. The relief rate for clinical symptoms in both groups was 98% and 98% respectively at one week finishing regimen （P 〉 0.05）, the ulcer healing rate in both groups was 93% and 76% （P 〈 0.05）, the global effective rate in both groups was 98%and 96% respectively （P 〉 0.05）. And the H pylori eradication rate in both groups was 85% and 81% respectively （P 〉 0.05）. Conclusion： Both regimens are effective for curing peptic ulcer, relieving symptoms, and for eradicating H pylor. Rabeprazole-based triple therapy is superior to lansoprazole-based triple therapy in improving symptoms and curing ulcers.
出处
《岭南急诊医学杂志》
2006年第1期34-36,共3页
Lingnan Journal of Emergency Medicine
