摘要
目的:探讨慢性丙肝患者血清谷丙转氨酶水平、丙肝病毒RNA定量对干扰素疗效的影响。方法:干扰素300万u肌肉注射,前4周1次/d,后20周隔日1次,治疗前后及停药24周检测患者血清谷丙转氨酶,丙肝病毒RNA定量。结果:血清丙肝病毒RNA定量<106cop ies/mL者比>106cop ies/mL者持续应答率高,血清谷丙转氨酶水平对干扰素疗效影响不大。结论:血清丙肝病毒RNA定量可作为持续应答的预测因子之一。
Objective To observe the relationship between serum HCVRNA load, ALT and effect of a interferon on the patients with chronic hepatitis C. Methods 3 MIU of a interferon was injected intramuscularly everyday for 4 weeks and every other day for 20 weeks. The quantitated and quanlitited HCVRNA were measured with PCR before and after therapy and 24 weeks after treatment. Results The rate of sustained response of HCVRNA was higher in lower titier group（≤10^6 copies/mL） than in high titier group（≥10^6copies/mL）. The response of ALT was not .related to the ALT level before therapy. Conclusion Serum factor of the effect of a interferon. HCVRNA load before therapy is an important forecast
出处
《实用诊断与治疗杂志》
2006年第3期187-188,共2页
Journal of Practical Diagnosis and Therapy
