摘要
目的研究胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、胰岛素与妊娠期糖尿病(GDM)的相关性。方法以30例GDM为GDM组,30名正常孕妇为对照组。两组孕妇于妊娠第31±1周,采用放射免疫法测母体血清胰岛素,酶联免疫吸附法测母体血清IGF_Ⅰ和足月分娩时的脐血清IGF_Ⅰ。结果GDM组与对照组相比,母血IGF_Ⅰ差异无统计学意义(P>0.05),LnIRI、脐血IGF_Ⅰ、新生儿体重均有显著性差异(P<0.01)。GDM组的母血IGF_Ⅰ和LnIRI成正相关(r=0.424,P<0.05),脐血IGF_Ⅰ和新生儿体重成正相关(r=0.434,P<0.05)。结论GDM存在严重的胰岛素抵抗(IR)。母血IGF_Ⅰ与GDM的IR存在相关性,脐血IGF_Ⅰ参与了GDM巨大儿的病理生理过程。IGF_Ⅰ可能是通过IR这条途径,使生长激素_胰岛素_胰岛素样生长因子轴失常,导致GDM的形成。
Objectives To research the correlation between insulin-like growth factor Ⅰ （IGF- Ⅰ ）, insulin and gestational diabetes mellitus （GDM）. Methods Thirty cases of GDM are taken as the GDM group. Thirty cases of normal pregnant women were taken as the control group. The insulin in maternal serum of these two groups were measured at 31 ± 1 weeks gestational age by radioimmunity. The IGF- Ⅰ in maternal serum at 31 ± lweeks gestational age and IGF- Ⅰ in umbilical serum at term delivery were measured by ELISA. Results There was no significant difference in IGF- Ⅰ level in maternal serum between the GDM group and the control group （P 〉0.05） and there was significant difference between these two groups maternal LnIRI, IGF- Ⅰ in umbilical serum and weight of new-born baby （P〈0.01）. In the GDM group, the IGF- Ⅰ in maternal serum positivly correlated with the LnIRI （r= 0. 424, P 〈 0.05） and IGF- Ⅰ in umbilical serum positivly correlated with the weight of new-born baby （ r = 0. 434, P 〈 0.05）. Conclusion GDM has serious insulin resistance. The IGF- Ⅰ in maternal serum correlated with the IR in GDM. IGF-Ⅰ in umbilical serum plays a role in the pathology and physiology process of fetal macrosomia. Abnormality of the axis of growth hormone-insulin-insulin-like growth factor caused by IGF- Ⅰ might be through the way of insulin resistance, and GDM is resulted.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2006年第1期89-91,共3页
Suzhou University Journal of Medical Science
