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促性腺激素释放激素拮抗剂在性早熟治疗中的研究进展 被引量:1

Progress on Treatment of Gonadotropin-Releasing Hormone Antagonists Precocious Puberty
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摘要 促性腺激素释放激素(GnRH)激动剂是目前治疗真性性早熟的首选药物。但是在使用初期会引起促性腺激素一过性升高(即flare-up效应),该效应不利于性早熟的治疗。动物实验和临床研究结果表明,GnRH拮抗剂对性激素有很强的抑制作用,并且无flare-up效应,因此成为更理想的替代GnRH激动剂治疗性早熟的药物。
作者 孙青 李海浪
出处 《国际儿科学杂志》 2006年第2期123-125,共3页 International Journal of Pediatrics
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