摘要
目的:探讨保守治疗异位妊娠的简便有效方法。方法:超声检查无胎心搏动和有胎心搏动异位妊娠患者按自愿原则分入A、B两组,A组患者,甲氨喋呤50 mg单次肌内注射,并同时服用米非司酮25 mg,Q 12 h×3 d,B组患者,甲氨喋呤50 mg超声引导注入妊娠囊,并同时服用米非司酮25 mg,Q 12 h×3 d。患者用药后严密观察腹痛、阴道出血及肛门坠胀感等表现,每天监测血压和脉搏,每3 d监测血β-HCG,每周监测阴道B超。结果:无胎心搏动患者中,甲氨喋呤超声引导注入妊娠囊配伍米非司酮组较甲氨喋呤单次肌内注射配伍米非司酮组有效率稍高(P>0.05),血HCG恢复至正常所需时间稍短,组间差异无显著的统计学意义(P>0.05);有胎心搏动患者中,甲氨喋呤超声引导注入妊娠囊配伍米非司酮组较甲氨喋呤单次肌内注射配伍米非司酮组有效率明显增高(P<0.05),血HCG恢复至正常所需时间短,组间差异有显著统计学意义(P<0.001)。结论:超声介入治疗具有定位准确,方法简便,操作时间短,创伤少,副作用少,恢复快等优点,可以作为异位妊娠的保守治疗方法之一,尤其对于有胎心搏动的异位妊娠治疗成功率较高,值得推广。
Objective： To evaluate the efficacy of conservative therapy of ectopic pregnancy. Methods： The cases of with or without cardiac activity were divided randomly into two groups. A singJe dose 50rag of Methotrexate was injected in group A and taken Mifepristone 25rag , Q12h ×3d. The cases of group B with 50rag Methotrexate injected into gestation sac under B ultrasonic and took Mifepristone 25mg , Q12h × 3d. After treated, these symptoms such as： bellyache , colporrhagia, anus bulge had been observed, blood tension and pulse monitored everyday, β-HCG checked every 3 days, B ultrasonic monitored every week. Results： those cases without cardiac activity, the efficacy of Group A was slight higher than group B （ P 〉 0. 05 ）, HCG recovered time of group A was shorter than group B, but the differentia had no significantly statistic meaning （ P 〉 0. 05 ） ; those cases with cardiac activity , the efficacy of Group A was higher than group B （ P 〈 0. 05 ）, HCG recovered time of group A was shorter than group B, but the differentia had significantly statistic meaning （ P 〈 0. 001 ） . Conclusion： Ultrasonic guided therapy with those advantages： orientation nicety, simple hess, short handletime , slight injury, slight side - effect, rapid recover, as a conservative management of ectopic pregnancy worthy of being generally used.
出处
《中国妇幼保健》
CAS
北大核心
2006年第6期838-839,共2页
Maternal and Child Health Care of China
基金
广东省医学科研基金立项课题〔项目编号20011223〕
关键词
异位妊娠
保守治疗
超声
Eetopic gestation g Conservative therapy
Ultrasonic
