摘要
目的通过对低温体外循环(CPB)和常温非CPB冠状动脉搭桥过程中的炎性介质前瞻性比较,观察两种不同搭桥方法炎性反应的程度。方法符合条件的冠脉搭桥患者随机、双盲、对照分为低温CPB组(组1)、常温非CPB组(组2),炎性介质:肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)在手术前、手术结束时、手术后4 h、手术后24 h进行比较。结果TNF-α、IL-6在两组间及同一组4个时间点均无统计学差异,IL-8在手术结束时均升高(两组间无差异),而在术后4 h即降到正常;两组的变化趋势一致。结论心脏搭桥手术过程中的炎症损伤,更主要来自于手术创伤本身,与是否应用体外循环关系不大。
OBJECTIVE To systemically compare the differences of Inflammatory medium levels between on - pump and off- pump CABG at the early post - operative stage. METHODS All of the patients who meet the criteria were divided into two groups （on -pump and off- pump CABG） randomly. To compare the cytokines （IL-6, IL- 8 ,TNF-α ） at four points of time between the two groups. RESULTS There were no difference on the TNF -α, IL - 6 at all of the time points. The IL -8 was higher at the end of operation （no -difference at two groups） ; on -pump and off-pump were no effect on the cytokines （ IL - 6, IL - 8, TNF - or） releasing. At the time of post operation, the IL - 8 were significantly increased in two groups （ no difference between two groups）. CONCLUSION Taken together, the lack of significant differences between the on - pump and off - pump groups suggests that other factors than CPB responsible for cytokines activation. The surgical trauma could be the more important contributing factor to the enhanced inflammatory response during cardiac surgery.
出处
《中国体外循环杂志》
2006年第1期23-25,29,共4页
Chinese Journal of Extracorporeal Circulation
