摘要
Objective To study the drug effects of “Caulis Sargentodoxae Formula” which clearsaway heat and blood clot on experimental endometriosis in rat, and to compare thiseffect with Danazol’s effects.Method The model of endometriosis rat was induced by transplanting with endometriumsurgically. The rats were divided into 6 groups randomly: the non-treatment group, thecastrate group, Danazol group(80 mg/kg), “Caulis Sargentodoxae Formula” group(110 g/kg), the medium dose group(77.5 g/kg) and the low dose group(55 g/kg). After3 weeks’ treatment, the volume of endometrium was detected by cutting the rats’ bellyopen, drawing the materials from endometrium for tissue section, and doing the quantityanalysis of endometrium by semiautomatic image analysis machine.Results There was no significant difference of the endometrium volumes between thelow dose group and the non-treatment group(P>0.05), other groups’ endometriumvolumes were significantly lower than those of the non-treatment group(P<0.05). Andapart from the low dose group, all other groups’ heights of the endometrium epitheliawere significantly lower than that of the non-treatment group(p<0.01).Conclusion “Caulis Sargentodoxae Formula” can refrain the growth of theendometrium, and the effects are better than that of Danazol’s.
Objective To study the drug effects of ＂Caulis Sargentodoxae Formula＂ which dears away heat and blood clot on experimental endometriosis in rat, and to compare this effect with Danazol＇s effects.
Method The model of endometriosis rat was induced by transplanting with endometrium surgically The rats were divided into 6 groups randomly： the non-treatment group, the castrate group, Danazol group（80 mg/kg）, ＂Caulis Sargentodoxae Formula＂ group （110 g/kg）, the medium dose group（77.5 g/kg） and the low dose group（55 g/kg）. After 3 weeks＇ treatment, the volume ofendometrium was detected by cutting the rats＇ belly open, drawing the materials from endometrium for tissue section, and doing the quantity analysis of endometrium by semiautomatic image analysis machine.
Results There was no significant difference of the endometrium volumes between the low dose group and the non-treatment group（P〉O.05）, other groups＇ endometrium volumes were significantly lower than those of the non-treatment group（P〈0. 05）. And apart from the low dose group, all other groups＇ heights of the endometrium epithelia were significantly lower than that of the non-treatment group（p〈0.01）.
Conclusion ＂Caulis Sargentodoxae Formula＂ can refrain the growth of the endometrium, and the effects are better than that of Danazol＇s.
